Disease relevance of cydA

• Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene [1].

High impact information on cydA

• Two classes of mutants which map to the cyd locus were obtained, cydA and cydB . The cydA phenotype included the lack of all three spectroscopically detectable cytochromes as well as the absence of both polypeptides, determined by immunological criteria [2].
• The protective effect of a deficiency of cydA at high temperature is itself suppressed by overexpression of cytochrome bo3, indicating that the phenomenon is related to energy metabolism rather than to a specific effect of the cydA protein [3].
• The cydA mutation protects a thymine-deficient strain from death in the absence of thymine on LB but not on minimal medium [3].
• The gene of cydA was expressed even under the condition of atmospheric pressure and its expression was enhanced with pressurization [4].
• Both nalidixic acid and novobiocin reduce cydA-lacZ expression in a concentration-dependent manner [5].

Chemical compound and disease context of cydA

• The cytochromes of membranes of the cydA mutant Escherichia coli GR19N grown on a proline-amino acid medium were examined [6].

Biological context of cydA

• In this paper we demonstrate that transcription from a cydA-lacZ gene fusion is not significantly affected in a cydD mutant [7].

References