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Gene Review

mutM  -  formamidopyrimidine-DNA glycosylase

Escherichia coli CFT073

 
 
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Disease relevance of mutM

  • Expression of the CiOgg1 significantly reduced the frequency of spontaneous G:C to T:A transversions in E. coli mutM mutY [1].
 

High impact information on mutM

 

Biological context of mutM

  • Strong mutator phenotypes of cells defective in both mutM and mutY genes or ones lacking mutT gene were completely suppressed under the anaerobic condition, indicative of an absence of hydroxyl radicals in the cells [5].
  • To test whether comparable residues and mechanisms might be operative for other BER glycosylase:AP-lyases, molecular modeling studies were conducted comparing the active site regions of T4-Pdg and the Escherichia coli formamidopyrimidine DNA glycosylase (Fpg) [6].
 

Associations of mutM with chemical compounds

  • Site-directed mutagenesis of the Fpg gene and analyses of the reaction mechanism of the mutant enzyme revealed that the H71A enzyme retained activity on a DNA substrate containing an 8-oxo-7,8-dihydroguanine (8-oxoG) opposite cytosine and DNA containing an AP site [6].
 

Analytical, diagnostic and therapeutic context of mutM

References

  1. Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihydroguanine in DNA in Ciona intestinalis. Jin, G., Zhang, Q.M., Satou, Y., Satoh, N., Kasai, H., Yonei, S. Int. J. Radiat. Biol. (2006) [Pubmed]
  2. High Resolution Characterization of Formamidopyrimidine-DNA Glycosylase Interaction with Its Substrate by Chemical Cross-linking and Mass Spectrometry Using Substrate Analogs. Rogacheva, M., Ishchenko, A., Saparbaev, M., Kuznetsova, S., Ogryzko, V. J. Biol. Chem. (2006) [Pubmed]
  3. Catalytic Mechanism of Escherichia coli Endonuclease VIII: Roles of the Intercalation Loop and the Zinc Finger. Kropachev, K.Y., Zharkov, D.O., Grollman, A.P. Biochemistry (2006) [Pubmed]
  4. Computational Analysis of the Mode of Binding of 8-Oxoguanine to Formamidopyrimidine-DNA Glycosylase. Song, K., Hornak, V., de Los Santos, C., Grollman, A.P., Simmerling, C. Biochemistry (2006) [Pubmed]
  5. Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli. Sakai, A., Nakanishi, M., Yoshiyama, K., Maki, H. Genes Cells (2006) [Pubmed]
  6. Modulation of the turnover of formamidopyrimidine DNA glycosylase. Harbut, M.B., Meador, M., Dodson, M.L., Lloyd, R.S. Biochemistry (2006) [Pubmed]
 
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