The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

mutM  -  formamidopyrimidine-DNA glycosylase

Escherichia coli CFT073

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of mutM

  • Expression of the CiOgg1 significantly reduced the frequency of spontaneous G:C to T:A transversions in E. coli mutM mutY [1].

High impact information on mutM


Biological context of mutM

  • Strong mutator phenotypes of cells defective in both mutM and mutY genes or ones lacking mutT gene were completely suppressed under the anaerobic condition, indicative of an absence of hydroxyl radicals in the cells [5].
  • To test whether comparable residues and mechanisms might be operative for other BER glycosylase:AP-lyases, molecular modeling studies were conducted comparing the active site regions of T4-Pdg and the Escherichia coli formamidopyrimidine DNA glycosylase (Fpg) [6].

Associations of mutM with chemical compounds

  • Site-directed mutagenesis of the Fpg gene and analyses of the reaction mechanism of the mutant enzyme revealed that the H71A enzyme retained activity on a DNA substrate containing an 8-oxo-7,8-dihydroguanine (8-oxoG) opposite cytosine and DNA containing an AP site [6].

Analytical, diagnostic and therapeutic context of mutM


  1. Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihydroguanine in DNA in Ciona intestinalis. Jin, G., Zhang, Q.M., Satou, Y., Satoh, N., Kasai, H., Yonei, S. Int. J. Radiat. Biol. (2006) [Pubmed]
  2. High Resolution Characterization of Formamidopyrimidine-DNA Glycosylase Interaction with Its Substrate by Chemical Cross-linking and Mass Spectrometry Using Substrate Analogs. Rogacheva, M., Ishchenko, A., Saparbaev, M., Kuznetsova, S., Ogryzko, V. J. Biol. Chem. (2006) [Pubmed]
  3. Catalytic Mechanism of Escherichia coli Endonuclease VIII: Roles of the Intercalation Loop and the Zinc Finger. Kropachev, K.Y., Zharkov, D.O., Grollman, A.P. Biochemistry (2006) [Pubmed]
  4. Computational Analysis of the Mode of Binding of 8-Oxoguanine to Formamidopyrimidine-DNA Glycosylase. Song, K., Hornak, V., de Los Santos, C., Grollman, A.P., Simmerling, C. Biochemistry (2006) [Pubmed]
  5. Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli. Sakai, A., Nakanishi, M., Yoshiyama, K., Maki, H. Genes Cells (2006) [Pubmed]
  6. Modulation of the turnover of formamidopyrimidine DNA glycosylase. Harbut, M.B., Meador, M., Dodson, M.L., Lloyd, R.S. Biochemistry (2006) [Pubmed]
WikiGenes - Universities