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Gene Review

nei  -  endonuclease VIII

Escherichia coli CFT073

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Disease relevance of nei


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Chemical compound and disease context of nei


Biological context of nei


Associations of nei with chemical compounds


Analytical, diagnostic and therapeutic context of nei


  1. Catalytic Mechanism of Escherichia coli Endonuclease VIII: Roles of the Intercalation Loop and the Zinc Finger. Kropachev, K.Y., Zharkov, D.O., Grollman, A.P. Biochemistry (2006) [Pubmed]
  2. Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate. Zharkov, D.O., Golan, G., Gilboa, R., Fernandes, A.S., Gerchman, S.E., Kycia, J.H., Rieger, R.A., Grollman, A.P., Shoham, G. EMBO J. (2002) [Pubmed]
  3. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. Takao, M., Kanno, S., Kobayashi, K., Zhang, Q.M., Yonei, S., van der Horst, G.T., Yasui, A. J. Biol. Chem. (2002) [Pubmed]
  4. Determination of active site residues in Escherichia coli endonuclease VIII. Burgess, S., Jaruga, P., Dodson, M.L., Dizdaroglu, M., Lloyd, R.S. J. Biol. Chem. (2002) [Pubmed]
  5. Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII. Hazra, T.K., Izumi, T., Venkataraman, R., Kow, Y.W., Dizdaroglu, M., Mitra, S. J. Biol. Chem. (2000) [Pubmed]
  6. Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals. Dizdaroglu, M., Burgess, S.M., Jaruga, P., Hazra, T.K., Rodriguez, H., Lloyd, R.S. Biochemistry (2001) [Pubmed]
  7. Spontaneous and osmium tetroxide-induced mutagenesis in an Escherichia coli strain deficient in both endonuclease III and endonuclease VIII. Najrana, T., Saito, Y., Uraki, F., Kubo, K., Yamamoto, K. Mutagenesis (2000) [Pubmed]
  8. Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants. Jiang, D., Hatahet, Z., Blaisdell, J.O., Melamede, R.J., Wallace, S.S. J. Bacteriol. (1997) [Pubmed]
  9. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. Bandaru, V., Sunkara, S., Wallace, S.S., Bond, J.P. DNA Repair (Amst.) (2002) [Pubmed]
  10. Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress. Rachek, L.I., Grishko, V.I., Alexeyev, M.F., Pastukh, V.V., LeDoux, S.P., Wilson, G.L. Nucleic Acids Res. (2004) [Pubmed]
  11. Isolation and characterization of endonuclease VIII from Escherichia coli. Melamede, R.J., Hatahet, Z., Kow, Y.W., Ide, H., Wallace, S.S. Biochemistry (1994) [Pubmed]
  12. Physical and functional interactions between Escherichia coli MutY and endonuclease VIII. Lu, A.L., Lee, C.Y., Li, L., Li, X. Biochem. J. (2006) [Pubmed]
  13. Novel repair activities of AlkA (3-methyladenine DNA glycosylase II) and endonuclease VIII for xanthine and oxanine, guanine lesions induced by nitric oxide and nitrous acid. Terato, H., Masaoka, A., Asagoshi, K., Honsho, A., Ohyama, Y., Suzuki, T., Yamada, M., Makino, K., Yamamoto, K., Ide, H. Nucleic Acids Res. (2002) [Pubmed]
  14. Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form. Golan, G., Zharkov, D.O., Fernandes, A.S., Zaika, E., Kycia, J.H., Wawrzak, Z., Grollman, A.P., Shoham, G. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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