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Gene Review

SPON2  -  spondin 2, extracellular matrix protein

Homo sapiens

Synonyms: DIL-1, DIL1, Differentially expressed in cancerous and non-cancerous lung cells 1, M-SPONDIN, MINDIN, ...
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Disease relevance of SPON2

  • Following analysis of the expression patterns of all selected and sequenced genes through interrogation of SAGE databases, a further three genes from our clone set, HOXB13, SPON2 and NCAM2, emerged as additional candidate markers of human prostate cancer [1].

High impact information on SPON2

  • Mindin(-/-) mice displayed defective CD4(+) T-cell priming and impaired humoral immune responses to T-dependent antigens [2].
  • DCs lacking beta(1) integrin had reduced adhesion to mindin matrix, decreased expression of Rac1/2 and impaired priming capacity [2].
  • Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors [3].
  • In disorgal1 ( dil1) and disorgal2 ( dil2) mutants the control of the mitotic division plane is relaxed or missing, resulting in mature grains with disorganized aleurone layers [4].
  • F-spondin and Mindin are evolutionarily conserved proteins [5].

Biological context of SPON2

  • In human beings, the FGFRL1 gene is located on chromosome 4, adjacent to the SPON2, CTBP1 and MEAEA genes [6].
  • Recent debate over the use of eyepads and mydriatics for corneal abrasions in ophthalmology departments (Mindin et al., 1996, JAMA 1996; 27: 837) has prompted this review of the management of small corneal abrasions (< 60% of cornea) in a large teaching hospital accident and emergency (A&E) department [7].

Anatomical context of SPON2

  • Macrophages of Mindin-deficient mice exhibit defective responses to a broad spectrum of microbial stimuli [5].

Other interactions of SPON2


  1. Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer. Edwards, S., Campbell, C., Flohr, P., Shipley, J., Giddings, I., Te-Poele, R., Dodson, A., Foster, C., Clark, J., Jhavar, S., Kovacs, G., Cooper, C.S. Br. J. Cancer (2005) [Pubmed]
  2. Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. Li, H., Oliver, T., Jia, W., He, Y.W. EMBO J. (2006) [Pubmed]
  3. Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer. Parry, R., Schneider, D., Hudson, D., Parkes, D., Xuan, J.A., Newton, A., Toy, P., Lin, R., Harkins, R., Alicke, B., Biroc, S., Kretschmer, P.J., Halks-Miller, M., Klocker, H., Zhu, Y., Larsen, B., Cobb, R.R., Bringmann, P., Roth, G., Lewis, J.S., Dinter, H., Parry, G. Cancer Res. (2005) [Pubmed]
  4. The maize disorganized aleurone layer 1 and 2 ( dil1, dil2) mutants lack control of the mitotic division plane in the aleurone layer of developing endosperm. Lid, S.E., Al, R.H., Krekling, T., Meeley, R.B., Ranch, J., Opsahl-Ferstad, H.G., Olsen, O.A. Planta (2004) [Pubmed]
  5. The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities. Feinstein, Y., Klar, A. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  6. Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. Trueb, B., Neuhauss, S.C., Baertschi, S., Rieckmann, T., Schild, C., Taeschler, S. Biochim. Biophys. Acta (2005) [Pubmed]
  7. The management of corneal abrasions in accident and emergency. Hart, A., White, S., Conboy, P., Quinton, D. Injury. (1997) [Pubmed]
  8. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. Manda, R., Kohno, T., Matsuno, Y., Takenoshita, S., Kuwano, H., Yokota, J. Genomics (1999) [Pubmed]
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