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Gene Review:

UBE2E3 - ubiquitin-conjugating enzyme E2E 3

Homo sapiens

Synonyms: UBCE4, UBCH9, UbcH9, UbcM2, Ubiquitin carrier protein E3, ...

Ito, K. et al., Ito, K. et al.

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Disease relevance of UBE2E3

A cDNA encoding a third member of human class III ubiquitin-conjugating enzymes (E2s), UBE2E3, was cloned from a human gastric adenocarcinoma cDNA library [1].

High impact information on UBE2E3

We have previously cloned cDNAs encoding the N-terminally extended class III human ubiquitin-conjugating enzymes (E2s), UBE2E2 and UBE2E3, the biological functions of which are not known [2].
Northern hybridization analysis exhibited a strong 1.9-kb band of UBE2E3 in skeletal muscle [1].
cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme [1].
Using FISH and PCR analysis of radiation hybrid and somatic cell hybrid panels the UBE2E3 gene was mapped to human chromosome 2q32.1 and showed strong linkage to SHGC-8506 (LOD = 11.52) between D2S1302 and D2S364 [1].
In addition, a UBE2E3 mutant of cysteine-145 to serine failed in UBE2E3-Ub complex formation, indicating that the cysteine is essential for E2 function [1].

References

cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme. Ito, K., Kato, S., Matsuda, Y., Kimura, M., Okano, Y. Cytogenet. Cell Genet. (1999) [Pubmed]
N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Ito, K., Adachi, S., Iwakami, R., Yasuda, H., Muto, Y., Seki, N., Okano, Y. Eur. J. Biochem. (2001) [Pubmed]

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FUS9	Arabidopsis thaliana
UBE2E3	Bos taurus
UBE2E3	Canis lupus familiaris
ube2e3	Danio rerio
UBE2E3	Gallus gallus
UBE2E3	Macaca mulatta
Ube2e3	Mus musculus
Os07g0577400	Oryza sativa Japonica Group
UBE2E3	Pan troglodytes
Ube2e3	Rattus norvegicus
ube2e3	Xenopus (Silurana) tropicalis

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