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Gene Review

UBE2E2  -  ubiquitin-conjugating enzyme E2E 2

Homo sapiens

Synonyms: FLJ25157, UBCH8, UbcH8, Ubiquitin carrier protein E2, Ubiquitin-conjugating enzyme E2 E2, ...
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High impact information on UBE2E2

  • Furthermore, these results raise the possibility that the ISG15 conjugation pathway might use UbcH8-competent Ub ligases in vivo [1].
  • Cys-194 lies within a region of identity to active-site Cys-88 of the ubiquitin carrier protein E2, suggesting a potential role for this region in enzymatic function of this protein [2].
  • Moreover, siRNA-mediated down-regulation of the major E2 for ISG15 (UbcH8), which blocked the formation of ISG15 protein conjugates, also increased the levels of polyubiquitinated proteins [3].
  • We have previously cloned cDNAs encoding the N-terminally extended class III human ubiquitin-conjugating enzymes (E2s), UBE2E2 and UBE2E3, the biological functions of which are not known [4].
  • In this study, we performed yeast two-hybrid screening for protein(s) interacting with UBE2E2, and two RING-finger proteins, ARA54 and RNF8, were identified [4].

Biological context of UBE2E2


Associations of UBE2E2 with chemical compounds

  • The Spen Homolog Msx2-Interacting Nuclear Target Protein Interacts with the E2 Ubiquitin-Conjugating Enzyme UbcH8 [6].

Analytical, diagnostic and therapeutic context of UBE2E2

  • The interaction between MINT and UbcH8 in mammalian cells was further proved by a series of biochemical assays including the mammalian two-hybrid assay, GST pull-down assay, and co-immunoprecipitation assay [6].


  1. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Zhao, C., Beaudenon, S.L., Kelley, M.L., Waddell, M.B., Yuan, W., Schulman, B.A., Huibregtse, J.M., Krug, R.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. Handley, P.M., Mueckler, M., Siegel, N.R., Ciechanover, A., Schwartz, A.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Desai, S.D., Haas, A.L., Wood, L.M., Tsai, Y.C., Pestka, S., Rubin, E.H., Saleem, A., Nur-E-Kamal, A., Liu, L.F. Cancer Res. (2006) [Pubmed]
  4. N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Ito, K., Adachi, S., Iwakami, R., Yasuda, H., Muto, Y., Seki, N., Okano, Y. Eur. J. Biochem. (2001) [Pubmed]
  5. cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. Kimura, M., Hattori, T., Matsuda, Y., Yoshioka, T., Sumi, N., Umeda, Y., Nakashima, S., Okano, Y. Cytogenet. Cell Genet. (1997) [Pubmed]
  6. The Spen Homolog Msx2-Interacting Nuclear Target Protein Interacts with the E2 Ubiquitin-Conjugating Enzyme UbcH8. Li, J., Wang, J., Yang, X., Li, J., Qin, H., Dong, X., Zhu, Y., Liang, L., Liang, Y., Han, H. Mol. Cell. Biochem. (2006) [Pubmed]
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