Disease relevance of CAP2

• Based on data from cobalt backfills and anti-CAP immunohistochemical staining, we propose that CAP2 exerts its effect on the larval hindgut at wandering via a local release from CAP-containing neurones in the terminal ganglion that project directly to the hindgut [1].

High impact information on CAP2

• Prostate ESTs are assembled into distinct species groups using the multiple alignment program CAP2 and are annotated with information from the GenBank, dbEST and Unigene public sequence databases [2].
• Expression of either human CAP or CAP2 in S. cerevisiae cap- strains suppresses phenotypes associated with deletion of the C-terminal domain of CAP, but does not restore hyper-activation of adenylyl cyclase by RAS2val19 [3].
• We provide several lines of evidence that this CAP2 drop is regulated by the insect steroid hormone 20-hydroxyecdysone (20-HE) [4].
• In larvae, the LNCs express high levels of a myoregulatory peptide, cardioacceleratory peptide 2 (CAP2) [4].
• Measurements of the amount of CAP2 in the central nervous system (CNS) of fifth-instar caterpillars revealed that CAP2 storage levels declined sharply on the day of gut emptying [1].

Biological context of CAP2

• Similarly, expression of either human CAP or CAP2 in S. pombe cap- strains suppresses the morphological and temperature-sensitive phenotypes associated with deletion of the C-terminal domain of CAP in this yeast [3].
• These two CAP bands of lysosomal origin appeared in sera of pregnant women at different times during the course of gestation; CAP1 band in the 3rd month and CAP2 band in the 6th month [5].

Anatomical context of CAP2

• The other two cystine aminopeptidase bands (CAP1 and CAP2), characteristic of pregnancy, were demonstrated in lysosomal extracts and hence suggested to be derived from the lysosomes of the placenta [5].

Associations of CAP2 with chemical compounds

• The CAP2 decline in the LNCs could be directly induced by exogenous steroid application, but only under conditions where the LNCs remained connected to the brain [4].

Analytical, diagnostic and therapeutic context of CAP2

• CAP2, when applied at physiological concentrations to an in vitro larval hindgut bioassay, caused changes in several parameters, including contraction frequency and amplitude, and basal tension [1].

References