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Gene Review

CCT7  -  chaperonin containing TCP1, subunit 7 (eta)

Homo sapiens

Synonyms: CCT-eta, CCTETA, CCTH, Ccth, HIV-1 Nef-interacting protein, ...
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Disease relevance of CCT7


High impact information on CCT7

  • Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis [1].
  • A fraction of Nip7p cosedimented through sucrose gradients with free 60S ribosomal subunits but not with 80S monosomes or polysomal ribosomes, indicating that it is not a ribosomal protein [1].
  • NIP7 encodes a 181-amino-acid protein (21 kDa) with homology to predicted products of open reading frames from humans, Caenorhabditis elegans, and Arabidopsis thaliana, indicating that Nip7p function is evolutionarily conserved [1].
  • Lastly, a 45% inhibition of sGC activity by CCTeta was seen in vivo in BE2 cells stably transfected with CCTeta and treated with sodium nitroprusside [2].
  • In vitro assays with purified CCTeta and Sf9 lysate expressing sGC resulted in a 30-50% inhibition of diethylamine diazeniumdiolate-NO-stimulated sGC activity [2].

Associations of CCT7 with chemical compounds

  • Furthermore, CCTeta had no effect on basal or sodium nitroprusside-stimulated alphabeta(Cys-105) sGC, a constitutively active mutant that only lacks the heme group [2].

Other interactions of CCT7

  • NIP-2 and NIP-7 GST fusion proteins effectively recognize NG2 in pull-down assays, demonstrating the ability of these polypeptide segments to interact with the intact proteoglycan [3].

Analytical, diagnostic and therapeutic context of CCT7

  • Nip7p was found evenly distributed throughout the cytoplasm and nucleus by indirect immunofluorescence; however, in vivo localization of a Nip7p-green fluorescent protein fusion protein revealed that a significant amount of Nip7p is present inside the nucleus, most probably in the nucleolus [1].


  1. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Zanchin, N.I., Roberts, P., DeSilva, A., Sherman, F., Goldfarb, D.S. Mol. Cell. Biol. (1997) [Pubmed]
  2. CCTeta, a novel soluble guanylyl cyclase-interacting protein. Hanafy, K.A., Martin, E., Murad, F. J. Biol. Chem. (2004) [Pubmed]
  3. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. Barritt, D.S., Pearn, M.T., Zisch, A.H., Lee, S.S., Javier, R.T., Pasquale, E.B., Stallcup, W.B. J. Cell. Biochem. (2000) [Pubmed]
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