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Chemical Compound Review

Diethamine     N-ethylethanamine

Synonyms: Diethylamin, Dietilamina, DIETHYLAMINE, Diaethylamin, Dwuetyloamina, ...
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Disease relevance of N-ethylethanamine


High impact information on N-ethylethanamine

  • Three NO donors, diethylamine NONOate, spermine NONOate, and S-nitrosoglutathione, exhibited concentration-dependent inhibition of both number of migrating VSMCs and maximal distance migrated [6].
  • In vitro assays with purified CCTeta and Sf9 lysate expressing sGC resulted in a 30-50% inhibition of diethylamine diazeniumdiolate-NO-stimulated sGC activity [7].
  • Simultaneous treatment with LPS and the NO donor, diethylamine NONOate (DEA/NO), enhanced and prolonged JNK and p38 phosphorylation [8].
  • We hypothesized that nitrosothiols that promote protein S-nitrosylation would reduce caspase-3 activation and cell survival, whereas nitric oxide donors (such as 1-propamine 3-(2-hydroxy-2-nitroso-1-propylhydrazine (PAPA) NONOate and diethylamine (DEA) NONOate) that do not target thiol residues would not [9].
  • In the presence of the NO.-generator diethylamine nonoate, the electron spin resonance spectrum of the PHS-2-derived tyrosyl radical is replaced by the spectrum of another free radical containing a nitrogen atom [10].

Chemical compound and disease context of N-ethylethanamine


Biological context of N-ethylethanamine


Anatomical context of N-ethylethanamine

  • We used the NO donor diethylamine dinitric oxide (DEA/NO) and the mouse macrophage cell line ANA-1 in these experiments [19].
  • Cholecystokinetic bile acid elevation was standardized by evacuating the gallbladder with intramuscular ceruletide diethylamine (cholecystokinin decapeptide) in a double-blind, randomized, placebo-controlled crossover design [20].
  • Vascular smooth-muscle relaxation to diethylamine was enhanced in endothelium-denuded HC vessel but was restored in pigs that were on the HC+vitamins regimen [21].
  • These include its ability to store zinc as a hydrophobic complex in membranes, its consumption of protons upon spontaneous decomposition, and the ability of one of its decomposition products, diethylamine, to accelerate the dissipation of pH gradients across lipid bilayers [22].
  • In the present work we found that similar in size and behavior tubulovesicular extensions were formed on the neutrophil cell bodies upon adhesion to fibronectin-coated substrata in the presence of the nitric oxide donor diethylamine NONOate [23].

Associations of N-ethylethanamine with other chemical compounds


Gene context of N-ethylethanamine

  • Differential expression of c-jun and c-myc in N-nitroso diethylamine-induced hepatic oncogenesis in AKR mice [29].
  • In the presence of diethylamine as model nucleophile, PLP-Br transformed PCBC to yield 2,3,4,4-tetrachlorothiobutenoic acid diethylamide; attempts to trap 1,2,3,4,4-pentachlorobutadienyl thiol, the initial metabolite formed by beta-elimination from PCBC, were unsuccessful [30].
  • In this study, we investigated the effect of the NO-releasing agent, diethylamine NONOate (NONO), on lymphocytes from patients affected by the sporadic form of ALS (SALS) and controls by flow cytometry [31].
  • An NO donor, diethylamine/NO complex (NOC 5), increased sTNF-RI in the supernatants of ECV304, a human umbilical vein cell line, in a dose-dependent manner [32].
  • An evaluation of the role of antiestrogen-binding sites in mediating the growth modulatory effects of antiestrogens: studies using t-butylphenoxyethyl diethylamine, a compound lacking affinity for the estrogen receptor [33].

Analytical, diagnostic and therapeutic context of N-ethylethanamine


  1. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat. Renner, I.G., Wisner, J.R., Rinderknecht, H. J. Clin. Invest. (1983) [Pubmed]
  2. Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase. Zhou, X., Espey, M.G., Chen, J.X., Hofseth, L.J., Miranda, K.M., Hussain, S.P., Wink, D.A., Harris, C.C. J. Biol. Chem. (2000) [Pubmed]
  3. Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Pagliaro, P., Mancardi, D., Rastaldo, R., Penna, C., Gattullo, D., Miranda, K.M., Feelisch, M., Wink, D.A., Kass, D.A., Paolocci, N. Free Radic. Biol. Med. (2003) [Pubmed]
  4. Relative avidity of serum immunoglobulin G antibody for the fimbria antigen of Actinobacillus actinomycetemcomitans in patients with adult periodontitis. Saito, A., Hosaka, Y., Nakagawa, T., Yamada, S., Okuda, K. Infect. Immun. (1993) [Pubmed]
  5. Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee. Niethard, F.U., Gold, M.S., Solomon, G.S., Liu, J.M., Unkauf, M., Albrecht, H.H., Elkik, F. J. Rheumatol. (2005) [Pubmed]
  6. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Sarkar, R., Meinberg, E.G., Stanley, J.C., Gordon, D., Webb, R.C. Circ. Res. (1996) [Pubmed]
  7. CCTeta, a novel soluble guanylyl cyclase-interacting protein. Hanafy, K.A., Martin, E., Murad, F. J. Biol. Chem. (2004) [Pubmed]
  8. Nuclear factor-kappa B and mitogen-activated protein kinases mediate nitric oxide-enhanced transcriptional expression of interferon-beta. Jacobs, A.T., Ignarro, L.J. J. Biol. Chem. (2003) [Pubmed]
  9. Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation. Zeigler, M.M., Doseff, A.I., Galloway, M.F., Opalek, J.M., Nowicki, P.T., Zweier, J.L., Sen, C.K., Marsh, C.B. J. Biol. Chem. (2003) [Pubmed]
  10. Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation. Gunther, M.R., Hsi, L.C., Curtis, J.F., Gierse, J.K., Marnett, L.J., Eling, T.E., Mason, R.P. J. Biol. Chem. (1997) [Pubmed]
  11. The avidity of specific IgM detected in primary rubella and reinfection. Thomas, H.I., Morgan-Capner, P. Epidemiol. Infect. (1990) [Pubmed]
  12. Leishmania spp.: mechanisms of toxicity of nitrogen oxidation products. Mauël, J., Ransijn, A. Exp. Parasitol. (1997) [Pubmed]
  13. The indeterminate breast mass: assessment using contrast enhanced magnetic resonance imaging. Hickman, P.F., Moore, N.R., Shepstone, B.J. The British journal of radiology. (1994) [Pubmed]
  14. In vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endothelium-dependent relaxations. Sato, J., Mohácsi, T., Noel, A., Jost, C., Gloviczki, P., Mozes, G., Katusic, Z.S., O'Brien, T., Mayhan, W.G. Stroke (2000) [Pubmed]
  15. Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat. Paton, J.F., Deuchars, J., Ahmad, Z., Wong, L.F., Murphy, D., Kasparov, S. J. Physiol. (Lond.) (2001) [Pubmed]
  16. Synergistic induction of DNA strand breakage by cigarette tar and nitric oxide. Yoshie, Y., Ohshima, H. Carcinogenesis (1997) [Pubmed]
  17. The effect of diethylamine on Stille alkylations with tetraalkylstannanes. Barros, M.T., Maycock, C.D., Madureira, M.I., Ventura, M.R. Chem. Commun. (Camb.) (2001) [Pubmed]
  18. Carbonyl- and carboxyl-substituted enediynes: synthesis, computations, and thermal reactivity. König, B., Pitsch, W., Klein, M., Vasold, R., Prall, M., Schreiner, P.R. J. Org. Chem. (2001) [Pubmed]
  19. Exogenous nitric oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages. Sheffler, L.A., Wink, D.A., Melillo, G., Cox, G.W. J. Immunol. (1995) [Pubmed]
  20. Bile acid levels in diagnosing mild liver disease. Fasting and postcholecystokinetic values. Simko, V., Michael, S. Arch. Intern. Med. (1986) [Pubmed]
  21. Renal vascular function in hypercholesterolemia is preserved by chronic antioxidant supplementation. Stulak, J.M., Lerman, A., Porcel, M.R., Caccitolo, J.A., Romero, J.C., Schaff, H.V., Napoli, C., Lerman, L.O. J. Am. Soc. Nephrol. (2001) [Pubmed]
  22. Mechanism of action of diabetogenic zinc-chelating agents. Model system studies. Epand, R.M., Stafford, A.R., Tyers, M., Nieboer, E. Mol. Pharmacol. (1985) [Pubmed]
  23. Scanning electron microscopy study of neutrophil membrane tubulovesicular extensions (cytonemes) and their role in anchoring, aggregation and phagocytosis. The effect of nitric oxide. Galkina, S.I., Molotkovsky, J.G., Ullrich, V., Sud'ina, G.F. Exp. Cell Res. (2005) [Pubmed]
  24. Elimination kinetics of disulfiram in alcoholics after single and repeated doses. Faiman, M.D., Jensen, J.C., Lacoursiere, R.B. Clin. Pharmacol. Ther. (1984) [Pubmed]
  25. Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. Sheffler, L.A., Wink, D.A., Melillo, G., Cox, G.W. J. Leukoc. Biol. (1995) [Pubmed]
  26. Secondary amine precursors to nitrosamines in human saliva, gastric juice, blood, urine and faeces. Tricker, A.R., Pfundstein, B., Kälble, T., Preussmann, R. Carcinogenesis (1992) [Pubmed]
  27. Acyl phosphatase activity of NO-inhibited glyceraldehyde-3-phosphate dehydrogenase (GAPDH): a potential mechanism for uncoupling glycolysis from ATP generation in NO-producing cells. Albina, J.E., Mastrofrancesco, B., Reichner, J.S. Biochem. J. (1999) [Pubmed]
  28. Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides. Sarkar, D., Vallance, P., Amirmansour, C., Harding, S.E. Cardiovasc. Res. (2000) [Pubmed]
  29. Differential expression of c-jun and c-myc in N-nitroso diethylamine-induced hepatic oncogenesis in AKR mice. Giri, R.K., Das, B.R. Cancer Lett. (1996) [Pubmed]
  30. Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-L-cysteine. Dekant, W., Berthold, K., Vamvakas, S., Henschler, D. Chem. Biol. Interact. (1988) [Pubmed]
  31. Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role? Cereda, C., Cova, E., Di Poto, C., Galli, A., Mazzini, G., Corato, M., Ceroni, M. Neurol. Sci. (2006) [Pubmed]
  32. Nitric oxide enhances expression and shedding of tumor necrosis factor receptor I (p55) in endothelial cells. Okuyama, M., Yamaguchi, S., Yamaoka, M., Nitobe, J., Fujii, S., Yoshimura, T., Tomoike, H. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  33. An evaluation of the role of antiestrogen-binding sites in mediating the growth modulatory effects of antiestrogens: studies using t-butylphenoxyethyl diethylamine, a compound lacking affinity for the estrogen receptor. Sheen, Y.Y., Simpson, D.M., Katzenellenbogen, B.S. Endocrinology (1985) [Pubmed]
  34. The effects of ceruletide in schizophrenia. Hommer, D.W., Pickar, D., Roy, A., Ninan, P., Boronow, J., Paul, S.M. Arch. Gen. Psychiatry (1984) [Pubmed]
  35. Ischemia reperfusion injury in tumors: the role of oxygen radicals and nitric oxide. Parkins, C.S., Dennis, M.F., Stratford, M.R., Hill, S.A., Chaplin, D.J. Cancer Res. (1995) [Pubmed]
  36. Reflux sign in cholescintigraphy after administration of a gallbladder contracting agent. Itoh, H., Murase, K., Hamamoto, K. J. Nucl. Med. (1989) [Pubmed]
  37. Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. Shan, S.Q., Rosner, G.L., Braun, R.D., Hahn, J., Pearce, C., Dewhirst, M.W. Br. J. Cancer (1997) [Pubmed]
  38. Physiological antagonism of endothelin-1 in human conductance and resistance coronary artery. Wiley, K.E., Davenport, A.P. Br. J. Pharmacol. (2001) [Pubmed]
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