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Gene Review

NRG3  -  neuregulin 3

Homo sapiens

Synonyms: HRG3, Pro-NRG3, Pro-neuregulin-3, membrane-bound isoform, pro-NRG3
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Disease relevance of NRG3

  • In this study we examined using immunohistochemical staining expression of NRG1alpha, NRG1beta, NRG2alpha, NRG2beta, NRG3 and NRG4 in sixty cases of pre-invasive ductal carcinoma in situ of the breast representing different degrees of differentiation [1].
  • Recombinant NRG-3 altered the growth of human breast cancer cells growing in vitro [2].
  • The EGF-like domain of NRG-3 was generated as a recombinant protein in E. coli and used to test the specificity of receptor binding [2].

High impact information on NRG3


Anatomical context of NRG3


Associations of NRG3 with chemical compounds


Other interactions of NRG3

  • High levels of expression of NRG2beta and NRG4 were associated with high-grade tumours (p</=0.005), NRG2beta staining was associated with tumour size >25 mm (p=0.005) while NRG3 nuclear staining was present more often in low-grade tumours (p=0.039) [1].


  1. Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast. Marshall, C., Blackburn, E., Clark, M., Humphreys, S., Gullick, W.J. Breast Cancer Res. Treat. (2006) [Pubmed]
  2. NRG-3 in human breast cancers: activation of multiple erbB family proteins. Hijazi, M.M., Young, P.E., Dougherty, M.K., Bressette, D.S., Cao, T.T., Pierce, J.H., Wong, L.M., Alimandi, M., King, C.R. Int. J. Oncol. (1998) [Pubmed]
  3. Ligand discrimination in signaling through an ErbB4 receptor homodimer. Sweeney, C., Lai, C., Riese, D.J., Diamonti, A.J., Cantley, L.C., Carraway, K.L. J. Biol. Chem. (2000) [Pubmed]
  4. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. Carteron, C., Ferrer-Montiel, A., Cabedo, H. J. Cell. Sci. (2006) [Pubmed]
  5. Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma. Mahtouk, K., Cremer, F.W., R??me, T., Jourdan, M., Baudard, M., Moreaux, J., Requirand, G., Fiol, G., De Vos, J., Moos, M., Quittet, P., Goldschmidt, H., Rossi, J.F., Hose, D., Klein, B. Oncogene (2006) [Pubmed]
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