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Gene Review

Minute  -  minute imprinted gene in the Igf2 region

Mus musculus

Synonyms: Mnt
 
 
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Disease relevance of Minute

  • RESULTS: Minute ventilation (VE) relative to baseline during hypercapnia from P2 through P7 was generally less than from P12.5 onwards, but there was no trough as in the rat [1].
 

High impact information on Minute

  • Here we show that in the mouse mutant Minute (Mnt) the Igf2-H19 locus acquires a paternal methylation imprint in the maternal germline [2].
  • Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute [3].
  • We have used this method to study the structure of Double Minute chromosomes (DMs) from the methotrexate (MTX)-resistant mouse cell line 3T6R50 [4].
  • RESULTS: Minute quantities of ethanol were detected in the breath of human subjects who had not consumed alcohol in the recent past [5].
  • METHODS: Minute-by-minute cardiac function is regulated by the beta-adrenergic receptor system, coupled to the adenylate cyclase and protein kinase (PK) A pathway via the Gs heterotrimeric G protein [6].

References

  1. Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65). Bissonnette, J.M., Knopp, S.J. Respir. Res. (2004) [Pubmed]
  2. Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA. Cerrato, F., Dean, W., Davies, K., Kagotani, K., Mitsuya, K., Okumura, K., Riccio, A., Reik, W. Hum. Mol. Genet. (2003) [Pubmed]
  3. Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Oliver, E.R., Saunders, T.L., Tarlé, S.A., Glaser, T. Development (2004) [Pubmed]
  4. Circular DNA of 3T6R50 double minute chromosomes. van der Bliek, A.M., Lincke, C.R., Borst, P. Nucleic Acids Res. (1988) [Pubmed]
  5. Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Nair, S., Cope, K., Risby, T.H., Diehl, A.M., Terence, R.H. Am. J. Gastroenterol. (2001) [Pubmed]
  6. Adrenergic pathways and left ventricular remodeling. Dorn, G.W. J. Card. Fail. (2002) [Pubmed]
 
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