Gene Review:
Igf2 - insulin-like growth factor 2
Mus musculus
Synonyms:
AL033362, IGF-II, Igf-2, Igf-II, Insulin-like growth factor II, ...
Shih,
Kulkarni,
Angiolini,
Sibley,
Reik,
Hovey,
Harris,
Hemberger,
Fowden,
Dean,
Zimmer,
Calzada-Wack,
Kappler,
Holzenberger,
Ozcan,
Sulimova,
Rostam Zadehl,
Fowden,
Smith,
Stewart,
Hadsell,
Wojnowski,
Penkov,
Smith,
Ormandy,
Zimmer,
Pfeifer,
Hughes,
Constância,
Szabó,
Sibley,
Ferguson-Smith,
Lee,
Magnuson,
Fundele,
Kelsey,
Constância,
Mann,
Hahn,
Quintanilla-Martinez,
Klimov,
Kelsey,
Dean,
Ishihara,
Sandovici,
Müller,
Sasaki,
Platonov,
Kahn,
Specht,
Samson,
Ferguson-Smith,
Vonderhaar,
Stoffel,
Reik,
Potter,
Kato,
- Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. Sun, F.L., Dean, W.L., Kelsey, G., Allen, N.D., Reik, W. Nature (1997)
- Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Harper, J., Burns, J.L., Foulstone, E.J., Pignatelli, M., Zaina, S., Hassan, A.B. Cancer Res. (2006)
- Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. Hahn, H., Wojnowski, L., Specht, K., Kappler, R., Calzada-Wack, J., Potter, D., Zimmer, A., Müller, U., Samson, E., Quintanilla-Martinez, L., Zimmer, A. J. Biol. Chem. (2000)
- Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. Devlin, A.M., Bottiglieri, T., Domann, F.E., Lentz, S.R. J. Biol. Chem. (2005)
- Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity. Jones, B.K., Levorse, J., Tilghman, S.M. Hum. Mol. Genet. (2001)
- Induction and peak gene expression of insulin-like growth factor II follow that of myogenin during differentiation of BC3H-1 muscle cells. Brown, E.J., Hsiao, D., Rosenthal, S.M. Biochem. Biophys. Res. Commun. (1992)
- Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Murrell, A., Heeson, S., Reik, W. Nat. Genet. (2004)
- CTCF maintains differential methylation at the Igf2/H19 locus. Schoenherr, C.J., Levorse, J.M., Tilghman, S.M. Nat. Genet. (2003)
- beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Kulkarni, R.N., Holzenberger, M., Shih, D.Q., Ozcan, U., Stoffel, M., Magnuson, M.A., Kahn, C.R. Nat. Genet. (2002)
- Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells. Zhang, Q., Tally, M., Larsson, O., Kennedy, R.T., Huang, L., Hall, K., Berggren, P.O. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Kaplan, P.J., Mohan, S., Cohen, P., Foster, B.A., Greenberg, N.M. Cancer Res. (1999)
- The role of the insulin-like growth factor system in adrenocortical tumourigenesis. Weber, M.M., Fottner, C., Wolf, E. Eur. J. Clin. Invest. (2000)
- Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. Stewart, C.E., Rotwein, P. J. Biol. Chem. (1996)
- Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains. Körner, C., Nürnberg, B., Uhde, M., Braulke, T. J. Biol. Chem. (1995)
- Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19. Constância, M., Dean, W., Lopes, S., Moore, T., Kelsey, G., Reik, W. Nat. Genet. (2000)
- Placental-specific IGF-II is a major modulator of placental and fetal growth. Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., Reik, W. Nature (2002)
- Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms. Szabó, P.E., Mann, J.R. Genes Dev. (1995)
- Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Tucker, K.L., Beard, C., Dausmann, J., Jackson-Grusby, L., Laird, P.W., Lei, H., Li, E., Jaenisch, R. Genes Dev. (1996)
- An enhancer deletion affects both H19 and Igf2 expression. Leighton, P.A., Saam, J.R., Ingram, R.S., Stewart, C.L., Tilghman, S.M. Genes Dev. (1995)
- Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Ripoche, M.A., Kress, C., Poirier, F., Dandolo, L. Genes Dev. (1997)
- Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C.P., Reik, W., Fowden, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans. Forné, T., Oswald, J., Dean, W., Saam, J.R., Bailleul, B., Dandolo, L., Tilghman, S.M., Walter, J., Reik, W. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Calvariae from fetal mice with a disrupted Igf1 gene have reduced rates of collagen synthesis but maintain responsiveness to glucocorticoids. Woitge, H.W., Kream, B.E. J. Bone Miner. Res. (2000)
- Modulation of Igf2 genomic imprinting in mice induced by 5-azacytidine, an inhibitor of DNA methylation. Hu, J.F., Nguyen, P.H., Pham, N.V., Vu, T.H., Hoffman, A.R. Mol. Endocrinol. (1997)
- Igf2 deficiency results in delayed lung development at the end of gestation. Silva, D., Venihaki, M., Guo, W.H., Lopez, M.F. Endocrinology (2006)
- Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Frasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I.D., Belfiore, A., Vigneri, R. Mol. Cell. Biol. (1999)
- cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. Khan, J., Bittner, M.L., Saal, L.H., Teichmann, U., Azorsa, D.O., Gooden, G.C., Pavan, W.J., Trent, J.M., Meltzer, P.S. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Elevation of cyclic AMP levels in mouse embryonic stem cells by insulin related peptides. Parkin, M.D., McNulty, S., Schofield, P.N. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. (1996)
- The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains. Pant, V., Mariano, P., Kanduri, C., Mattsson, A., Lobanenkov, V., Heuchel, R., Ohlsson, R. Genes Dev. (2003)
- Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation. Sasaki, H., Ishihara, K., Kato, R. J. Biochem. (2000)
- Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region. Szabó, P.E., Pfeifer, G.P., Mann, J.R. Mol. Cell. Biol. (2004)
- IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6. Armand, A.S., Lécolle, S., Launay, T., Pariset, C., Fiore, F., Della Gaspera, B., Birnbaum, D., Chanoine, C., Charbonnier, F. Exp. Cell Res. (2004)
- TGFalpha reactivates imprinted Igf2 in the parthenogenetic mice embryos and placenta. Rostam Zadehl, J., Penkov, L.I., Klimov, E.A., Platonov, E.S., Sulimova, G.E. Genetika (2005)
- Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Hovey, R.C., Harris, J., Hadsell, D.L., Lee, A.V., Ormandy, C.J., Vonderhaar, B.K. Mol. Endocrinol. (2003)
- The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns. Greally, J.M., Starr, D.J., Hwang, S., Song, L., Jaarola, M., Zemel, S. Hum. Mol. Genet. (1998)
- Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Biniszkiewicz, D., Gribnau, J., Ramsahoye, B., Gaudet, F., Eggan, K., Humpherys, D., Mastrangelo, M.A., Jun, Z., Walter, J., Jaenisch, R. Mol. Cell. Biol. (2002)
- Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA. Cerrato, F., Dean, W., Davies, K., Kagotani, K., Mitsuya, K., Okumura, K., Riccio, A., Reik, W. Hum. Mol. Genet. (2003)
- Genomic imprinting controls matrix attachment regions in the Igf2 gene. Weber, M., Hagège, H., Murrell, A., Brunel, C., Reik, W., Cathala, G., Forné, T. Mol. Cell. Biol. (2003)
- Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Hassan, A.B., Howell, J.A. Cancer Res. (2000)
- Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice. Lahm, H., Gittner, K., Krebs, O., Sprague, L., Deml, E., Oesterle, D., Hoeflich, A., Wanke, R., Wolf, E. Growth Horm. IGF Res. (2002)
- Expression of H19 and Igf2 genes in uniparental mouse ES cells during in vitro and in vivo differentiation. McKarney, L.A., Overall, M.L., Dziadek, M. Differentiation (1996)