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Gene Review

Pttg1ip  -  pituitary tumor-transforming 1 interacting...

Mus musculus

Synonyms: 1810010L20Rik, AI314311, AU018448, C79540, PBF, ...
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Disease relevance of Pttg1ip

  • CONCLUSION: This study demonstrated that PBF has strong activities against hypercholesterolemia, obesity, and gallstone formation, suggesting a potential usefulness of PBF as functional ingredient [1].

High impact information on Pttg1ip

  • The gene for Pttg1ip was upregulated in Runx2-expressing cells [2].
  • Pttg1ip is widely expressed during development, but at highest levels in limbs and gonads [2].
  • Mutational analyses in conjunction with transient transfection assays indicated that the factor that binds to the region between -245 to -242 (PBF II) plays a positive regulatory role p53 promoter activity [3].
  • These two sites are referred to as binding sites for PBF I and II, respectively [3].
  • OBJECTIVE: This study evaluated the physiologic properties of high protein buckwheat flour (PBF) by examining its effects on serum cholesterol and body fat in rats and on cholesterol gallstone formation in mice [1].

Anatomical context of Pttg1ip

  • In experiment 2, consumption of PBF for 10 d significantly suppressed adipose tissue weight and hepatic activity of fatty acid synthase in rats fed cholesterol-free diets compared with consumption of casein (P < 0.05), whereas that of BWP for this period caused only a slight decrease in adipose tissue weight (P > 0.05) [1].

Associations of Pttg1ip with chemical compounds

  • RESULTS: In experiment 1, consumption of PBF and BWP for 10 d caused 33% and 31% decreases, respectively, in serum cholesterol of rats fed cholesterol-enriched diets when compared with consumption of casein (P < 0.05) [1].

Other interactions of Pttg1ip

  • Therefore, Pttg1ip is likely tobe a novel direct transcriptional target gene of Runx2 [2].


  1. High protein buckwheat flour suppresses hypercholesterolemia in rats and gallstone formation in mice by hypercholesterolemic diet and body fat in rats because of its low protein digestibility. Tomotake, H., Yamamoto, N., Yanaka, N., Ohinata, H., Yamazaki, R., Kayashita, J., Kato, N. Nutrition (Burbank, Los Angeles County, Calif.) (2006) [Pubmed]
  2. Identification of novel genes of the bone-specific transcription factor Runx2. Stock, M., Schäfer, H., Fliegauf, M., Otto, F. J. Bone Miner. Res. (2004) [Pubmed]
  3. Positive and negative regulatory elements in the murine p53 promoter. Roy, B., Reisman, D. Oncogene (1996) [Pubmed]
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