Disease relevance of PTTG1IP

• RESULTS: PBF mRNA expression was higher in differentiated thyroid carcinomas than in normal thyroid (P < 0.001; n = 27) and was independently associated with tumor recurrence (P = 0.002; R(2) = 0.49) [1].
• We also demonstrated that PBF was similarly raised in adenomas (sixfold, P = 0.0001), and was significantly correlated with PTTG expression [2].
• METHODS: Total body fat (TBF) (in kilograms) and percent of body weight as fat (PBF) were estimated by dual energy x-ray absorptiometry (DXA) in 198 healthy Italian children and adolescents between 5 and 19 years of age [3].
• MATERIAL AND METHOD: This study was conducted on 50 PBF confirmed cases of Plasmodium falciparum malaria with jaundice [4].
• Non-tumorous arterial blood flow and PBF were 39.07 and 62.74 mL/100 g/minute in the segment with metastases, and 41.95 and 66.23 mL/100 g/minute without metastases [5].

High impact information on PTTG1IP

• The PTTG binding domain in PBF was located within the C-terminal 30-amino acid region that contain a nuclear localization signal [6].
• Furthermore, PBF is required for transcriptional activation of basic fibroblast growth factor by PTTG [6].
• PBF contains an open reading frame of 179 amino acids with a predicted molecular mass of 22 kDa [6].
• Glutathione S-transferase pull-down and co-immunoprecipitation assays demonstrate that PBF interacts specifically with PTTG under both in vitro and in vivo conditions [6].
• OBJECTIVE: The aim of this study was to ascertain whether PBF expression is associated with thyroid cancer outcome [1].

Biological context of PTTG1IP

• The results show that PTTG1 and its binding protein PTTG binding factor are expressed in pituitary FS TtT/GF cells [7].
• The C21orf3 gene encodes a predicted protein of 180 residues that does not share any sequence homology with other known proteins [8].
• C21orf3 harbors predicted structural features of a type Ia integral membrane protein and contains a tetrapeptide motif (YXRF) observed in several cell surface proteins involved in signal transduction [8].
• Respiratory rate, tidal volume, dynamic lung compliance, functional residual capacity, and pulmonary resistance were measured withim 24 hours of cardiac catheterization in 25 infants, 12 of whom had increased pulmonary blood flow and 13 of whom had decreased PBF [9].
• Each lung volume was divided into three regions (anterior, middle, posterior), and the following parameters were assessed: Time-to-Peak (TTP), blood flow (PBF), blood volume (PBV), and mean transit time (MTT) [10].

Anatomical context of PTTG1IP

• PTTG expression was higher in malignant cells than in primary astrocytes, whereas PTTG-binding factor was not [11].
• The decrease in CL in infants with increased PBF significantly correlated with mean pulmonary artery pressure (r = 0.798) [9].
• METHODS: The authors used LDF to assess the PBF values of avulsed permanent maxillary incisors treated using replantation and splinting in 17 subjects [12].

Regulatory relationships of PTTG1IP

• PTTG was able to up-regulate PBF mRNA expression in vitro (P < 0.001; n = 12), and stable overexpression of PBF in NIH3T3 cells resulted in significant colony formation (P < 0.001; n = 12) [1].

Other interactions of PTTG1IP

• FGF-2 protein was concordantly lower in fetal cortex, whereas pretranslational expression of PTTG binding factor (PBF) was not significantly altered in fetal brain compared with adult [13].
• Immunofluorescence and subcellular fractionation studies showed that PTTG is predominantly expressed in the cytoplasm with partial nuclear localization, whereas PBF is localized both in the cytoplasm and the nucleus [6].

Analytical, diagnostic and therapeutic context of PTTG1IP

• In Northern blot analyses, PBF mRNA was ubiquitously expressed in human tissues [6].
• BACKGROUND: Laser Doppler flowmetry, or LDF, is a noninvasive method used to assess pulpal blood flow, or PBF [12].
• Five variables were selected as factors affecting postoperative TBPC; bleeding volume (BLD), warm ischemic time (WIT), cold ischemic time (CIT), graft weight/standard liver volume ratio (GW/SLV), and portal blood flow after surgery (PBF) [14].

References