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Gene Review

PTTG1IP  -  pituitary tumor-transforming 1 interacting...

Homo sapiens

Synonyms: C21orf1, C21orf3, PBF, PTTG-binding factor, Pituitary tumor-transforming gene 1 protein-interacting protein, ...
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Disease relevance of PTTG1IP

  • RESULTS: PBF mRNA expression was higher in differentiated thyroid carcinomas than in normal thyroid (P < 0.001; n = 27) and was independently associated with tumor recurrence (P = 0.002; R(2) = 0.49) [1].
  • We also demonstrated that PBF was similarly raised in adenomas (sixfold, P = 0.0001), and was significantly correlated with PTTG expression [2].
  • METHODS: Total body fat (TBF) (in kilograms) and percent of body weight as fat (PBF) were estimated by dual energy x-ray absorptiometry (DXA) in 198 healthy Italian children and adolescents between 5 and 19 years of age [3].
  • MATERIAL AND METHOD: This study was conducted on 50 PBF confirmed cases of Plasmodium falciparum malaria with jaundice [4].
  • Non-tumorous arterial blood flow and PBF were 39.07 and 62.74 mL/100 g/minute in the segment with metastases, and 41.95 and 66.23 mL/100 g/minute without metastases [5].

High impact information on PTTG1IP


Biological context of PTTG1IP


Anatomical context of PTTG1IP


Regulatory relationships of PTTG1IP

  • PTTG was able to up-regulate PBF mRNA expression in vitro (P < 0.001; n = 12), and stable overexpression of PBF in NIH3T3 cells resulted in significant colony formation (P < 0.001; n = 12) [1].

Other interactions of PTTG1IP

  • FGF-2 protein was concordantly lower in fetal cortex, whereas pretranslational expression of PTTG binding factor (PBF) was not significantly altered in fetal brain compared with adult [13].
  • Immunofluorescence and subcellular fractionation studies showed that PTTG is predominantly expressed in the cytoplasm with partial nuclear localization, whereas PBF is localized both in the cytoplasm and the nucleus [6].

Analytical, diagnostic and therapeutic context of PTTG1IP

  • In Northern blot analyses, PBF mRNA was ubiquitously expressed in human tissues [6].
  • BACKGROUND: Laser Doppler flowmetry, or LDF, is a noninvasive method used to assess pulpal blood flow, or PBF [12].
  • Five variables were selected as factors affecting postoperative TBPC; bleeding volume (BLD), warm ischemic time (WIT), cold ischemic time (CIT), graft weight/standard liver volume ratio (GW/SLV), and portal blood flow after surgery (PBF) [14].


  1. Pituitary tumor transforming gene binding factor: a novel transforming gene in thyroid tumorigenesis. Stratford, A.L., Boelaert, K., Tannahill, L.A., Kim, D.S., Warfield, A., Eggo, M.C., Gittoes, N.J., Young, L.S., Franklyn, J.A., McCabe, C.J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  2. Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour. McCabe, C.J., Khaira, J.S., Boelaert, K., Heaney, A.P., Tannahill, L.A., Hussain, S., Mitchell, R., Olliff, J., Sheppard, M.C., Franklyn, J.A., Gittoes, N.J. Clin. Endocrinol. (Oxf) (2003) [Pubmed]
  3. Body mass index as a measure of adiposity among children and adolescents: a validation study. Pietrobelli, A., Faith, M.S., Allison, D.B., Gallagher, D., Chiumello, G., Heymsfield, S.B. J. Pediatr. (1998) [Pubmed]
  4. Malarial hepatitis. Kochar, D.K., Singh, P., Agarwal, P., Kochar, S.K., Pokharna, R., Sareen, P.K. The Journal of the Association of Physicians of India. (2003) [Pubmed]
  5. Changes in hepatic parenchymal blood flow with colorectal metastases: increase in arterial and decrease in portal blood flow. Kunishima, S., Taniguchi, H., Yamaguchi, A., Koh, T., Yamagishi, H. Hepatogastroenterology (2003) [Pubmed]
  6. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. Chien, W., Pei, L. J. Biol. Chem. (2000) [Pubmed]
  7. Mechanisms for Growth Factor-Induced Pituitary Tumor Transforming Gene-1 Expression in Pituitary Folliculostellate TtT/GF Cells. Vlotides, G., Cruz-Soto, M., Rubinek, T., Eigler, T., Auernhammer, C.J., Melmed, S. Mol. Endocrinol. (2006) [Pubmed]
  8. Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. Yaspo, M.L., Aaltonen, J., Horelli-Kuitunen, N., Peltonen, L., Lehrach, H. Genomics (1998) [Pubmed]
  9. Lung mechanics in congenital heart disease with increased and decreased pulmonary blood flow. Bancalari, E., Jesse, M.J., Gelband, H., Garcia, O. J. Pediatr. (1977) [Pubmed]
  10. Quantitative 3D pulmonary MR-perfusion in patients with pulmonary arterial hypertension: Correlation with invasive pressure measurements. Ley, S., Mereles, D., Risse, F., Grünig, E., Ley-Zaporozhan, J., Tecer, Z., Puderbach, M., Fink, C., Kauczor, H.U. European journal of radiology (2007) [Pubmed]
  11. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Tfelt-Hansen, J., Yano, S., Bandyopadhyay, S., Carroll, R., Brown, E.M., Chattopadhyay, N. Endocrinology (2004) [Pubmed]
  12. Assessing revascularization of avulsed permanent maxillary incisors by laser Doppler flowmetry. Strobl, H., Gojer, G., Norer, B., Emshoff, R. Journal of the American Dental Association (1939) (2003) [Pubmed]
  13. A potential role for PTTG/securin in the developing human fetal brain. Boelaert, K., Tannahill, L.A., Bulmer, J.N., Kachilele, S., Chan, S.Y., Kim, D., Gittoes, N.J., Franklyn, J.A., Kilby, M.D., McCabe, C.J. FASEB J. (2003) [Pubmed]
  14. Total body propofol clearance (TBPC) after living-donor liver transplantation (LDLT) surgery is decreased in patients with a long warm ischemic time. Al-Jahdari, W.S., Kunimoto, F., Saito, S., Yamamoto, K., Koyama, H., Horiuchi, R., Goto, F. Journal of anesthesia. (2006) [Pubmed]
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