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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Es2  -  esterase 2

Mus musculus

Synonyms: Es-2
 
 
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High impact information on Es2

  • These data suggest that a gene located on chromosome 7 encodes a trans-acting regulatory factor that might be a negative effector of the Nmo-1 gene, which we show here is located on chromosome 8 approximately 1.4 centimorgans (about 1000 kilobase pairs) from the Es-2 gene [1].
  • Interestingly, expression of the adjacent Es2 gene in the pons region of Gscl null fetuses was absent, suggesting that mutations within the DGS/VCFS region can influence expression of adjacent genes [2].
  • Mapping of the LCAT gene (Lcat) to mouse Chromosome 8 within 2 centimorgans of the Es-2 locus indicates that it does not correspond to any previously mapped loci affecting high density lipoprotein phenotypes in the mouse [3].
  • LG VI now contains five loci with the following order and intervening map distances: Es-1, Es-2 complex--6.3 +/- 2.1 cM--Est-1, Est-2 complex--18.5 +/- 3.7 cM--e [4].
  • Homology modeling and active-site residues probing of the thermophilic Alicyclobacillus acidocaldarius esterase 2 [5].
 

Biological context of Es2

 

Other interactions of Es2

  • 4. Recombination studies on a further 129 animals confirmed that the Es-7 locus is tightly linked to Es-2 and Es-11 [8].
  • In backcrosses, ES-11 segregates as an autosomal gene, designated Es-11, closely linked to Es-2 and Es-5 on chromosome 8 [9].
  • Locus Es-30 is shown to be closely linked to Es-2 and to Es-7 of cluster-2 on chromosome 8 [10].
  • With the non selectively staining Q-O-2 several esterases were demonstrated Es-2, adn Es-9 among them [11].

References

  1. Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. Petersen, D.D., Gonzalez, F.J., Rapic, V., Kozak, C.A., Lee, J.Y., Jones, J.E., Nebert, D.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes. Wakamiya, M., Lindsay, E.A., Rivera-Pérez, J.A., Baldini, A., Behringer, R.R. Hum. Mol. Genet. (1998) [Pubmed]
  3. Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin: cholesterol acyltransferase gene. Evidence for expression in brain and testes as well as liver. Warden, C.H., Langner, C.A., Gordon, J.I., Taylor, B.A., McLean, J.W., Lusis, A.J. J. Biol. Chem. (1989) [Pubmed]
  4. Chromosomal homology of rabbit (Oryctolagus cuniculus) linkage group VI with rodent species. Fox, R.R., van Zutphen, L.F. Genetics (1979) [Pubmed]
  5. Homology modeling and active-site residues probing of the thermophilic Alicyclobacillus acidocaldarius esterase 2. Manco, G., Febbraio, F., Adinolfi, E., Rossi, M. Protein Sci. (1999) [Pubmed]
  6. Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8. Watanabe, T., Ogasawara, N., Goto, H. Biochem. Genet. (1976) [Pubmed]
  7. Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobin in the rat. Otsen, M., Den Bieman, M., van Zutphen, L.F. J. Hered. (1993) [Pubmed]
  8. Esterase-7, a common constituent of numerous mouse tissues. Lipps, A., Ronai, A., von Deimling, O. Comp. Biochem. Physiol., B (1979) [Pubmed]
  9. Polymorphism of esterase 11 in Mus musculus, a further esterase locus on chromosome 8. Peters, J., Nash, H.R. Biochem. Genet. (1977) [Pubmed]
  10. Esterase-30 (ES-30) of the house mouse: biochemical characterization and genetics of a new carboxylesterase isozyme linked to cluster-2 loci on chromosome 8. Ronai, A., Berning, W., Gaa, A., von Deimling, O. Biochem. Genet. (1993) [Pubmed]
  11. Esterase. XXIII. Electron microscopical demonstration of non-specific esterases in the jejunum of the mouse (Mus musc.) with two quinoline derivatives. Böcking, A., Grossarth, C., Deimling, O.V. Histochemistry (1976) [Pubmed]
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