Disease relevance of ACTR3B

• Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells [1].

High impact information on ACTR3B

• The Arp11 gene was mapped to human chromosome 7q32-36 [2].
• An ARP3beta pseudogene was detected on chromosome 2p11 by database searching [3].
• Gene structure analysis revealed that at least part of the observed ARP3beta mRNA heterogeneity is caused by alternative splicing resulting in exon skipping [3].
• Using in situ hybridization, the expression of ARP3beta in brain was shown to be restricted to neurons and epithelial cells from choroid plexus [3].
• This suggests a specific function for ARP3beta in the physiology of the development and/or maintenance of distinct subsets of nerve cells [3].

Anatomical context of ACTR3B

• Several ARP3beta mRNA species were detected by Northern blotting and their abundance varied importantly among tissues: the highest expression levels were detected in fetal and adult brain, whereas lower levels were observed in liver, muscle and pancreas [3].

Analytical, diagnostic and therapeutic context of ACTR3B

• Southern blot and PCR analyses show that all of the high-metastatic variant cells have not rearrangements and deletions of Arp11 allele [2].

References