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Gene Review:

Evi11 - ecotropic viral integration site 11

Mus musculus

Valk, P.J. et al., Valk, P.J. et al., Jorda, M.A. et al., Joosten, M. et al., Valk, P.J. et al.

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Disease relevance of Evi11

A new common region of virus integration, Evi11, has been identified in two retrovirally induced murine myeloid leukemia cell lines, NFS107 and NFS78 [1].
By means of retroviral insertional mutagenesis, we identified a novel common virus integration site (cVIS) (Evi11) in murine leukemias, and demonstrated that Cb2, encoding the peripheral cannabinoid receptor, is the potential proto-oncogene located in that region [2].
Multiple provirus insertions in Evi11 were cloned and shown to be located within the 3' untranslated region of the candidate proto-oncogene Cnr2 [3].
OBJECTIVE: The gene encoding the peripheral cannabinoid receptor Cb2 is located in the common virus integration site Evi11 and is associated with hematopoietic malignancies in mice [4].

High impact information on Evi11

The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also referred to as Cb2) [3].
By interspecific backcross analysis, it was shown that Evi11 is located at the distal end of mouse chromosome 4, in a region that shows homology with human 1p36 [1].

Biological context of Evi11

Following retroviral insertional mutagenesis we recently identified the gene encoding the peripheral cannabinoid receptor (Cb2) near a common virus integration site (VIS), Evi11 [5].

References

The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11. Valk, P.J., Hol, S., Vankan, Y., Ihle, J.N., Askew, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., de Both, N.J., Löwenberg, B., Delwel, R. J. Virol. (1997) [Pubmed]
Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. Jorda, M.A., Rayman, N., Valk, P., De Wee, E., Delwel, R. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. Valk, P.J., Vankan, Y., Joosten, M., Jenkins, N.A., Copeland, N.G., Löwenberg, B., Delwel, R. J. Virol. (1999) [Pubmed]
Leukemic predisposition of pSca-1/Cb2 transgenic mice. Joosten, M., Valk, P.J., Jordà, M.A., Vankan-Berkhoudt, Y., Verbakel, S., van den Broek, M., Beijen, A., Löwenberg, B., Delwel, R. Exp. Hematol. (2002) [Pubmed]
The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis. Valk, P.J., Delwel, R. Leuk. Lymphoma (1998) [Pubmed]

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