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Gene Review

Evi11  -  ecotropic viral integration site 11

Mus musculus

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Disease relevance of Evi11


High impact information on Evi11

  • The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also referred to as Cb2) [3].
  • By interspecific backcross analysis, it was shown that Evi11 is located at the distal end of mouse chromosome 4, in a region that shows homology with human 1p36 [1].

Biological context of Evi11


  1. The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11. Valk, P.J., Hol, S., Vankan, Y., Ihle, J.N., Askew, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., de Both, N.J., Löwenberg, B., Delwel, R. J. Virol. (1997) [Pubmed]
  2. Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. Jorda, M.A., Rayman, N., Valk, P., De Wee, E., Delwel, R. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  3. Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. Valk, P.J., Vankan, Y., Joosten, M., Jenkins, N.A., Copeland, N.G., Löwenberg, B., Delwel, R. J. Virol. (1999) [Pubmed]
  4. Leukemic predisposition of pSca-1/Cb2 transgenic mice. Joosten, M., Valk, P.J., Jordà, M.A., Vankan-Berkhoudt, Y., Verbakel, S., van den Broek, M., Beijen, A., Löwenberg, B., Delwel, R. Exp. Hematol. (2002) [Pubmed]
  5. The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis. Valk, P.J., Delwel, R. Leuk. Lymphoma (1998) [Pubmed]
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