Gene Review:
Cnr1 - cannabinoid receptor 1 (brain)
Mus musculus
Synonyms:
Brain-type cannabinoid receptor, CB-R, CB1, CB1R, Cannabinoid receptor 1
Barbaccia,
Advani,
Shelton,
Pacher,
Hungund,
Derocq,
Marchand,
Wallace,
Harvey-White,
Osei-Hyiaman,
Ledent,
Szakall,
Murray,
Davis,
Offertáler,
Casellas,
Leid,
Felder,
Járai,
Lichtman,
Jo,
Carlisle,
Bátkai,
Vadasz,
Adam,
Liu,
Matveyeva,
Role,
McCoy,
Rinaldi-Carmona,
Bouaboula,
Glass,
Moore,
Soderstrom,
Cravatt,
Castañé,
Chen,
Talmage,
Parmentier,
Chua,
Basavarajappa,
Hornby,
Ségui,
Kimball,
Cravatt,
Ronesi,
Maldonado,
Cabral,
Finazzi-Agrò,
Kunos,
Maccarrone,
Schneider,
Valverde,
Lovinger,
Brassai,
- CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Teixeira-Clerc, F., Julien, B., Grenard, P., Tran Van Nhieu, J., Deveaux, V., Li, L., Serriere-Lanneau, V., Ledent, C., Mallat, A., Lotersztajn, S. Nat. Med. (2006)
- The endogenous cannabinoid system protects against colonic inflammation. Massa, F., Marsicano, G., Hermann, H., Cannich, A., Monory, K., Cravatt, B.F., Ferri, G.L., Sibaev, A., Storr, M., Lutz, B. J. Clin. Invest. (2004)
- A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in ERK activation by cannabinoid receptor 1 in N1E-115 neuroblastoma cells. Davis, M.I., Ronesi, J., Lovinger, D.M. J. Biol. Chem. (2003)
- Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. Osei-Hyiaman, D., Liu, J., Zhou, L., Godlewski, G., Harvey-White, J., Jeong, W.I., Bátkai, S., Marsicano, G., Lutz, B., Buettner, C., Kunos, G. J. Clin. Invest. (2008)
- Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.F., Beslot, F., Böhme, G.A., Imperato, A., Pedrazzini, T., Roques, B.P., Vassart, G., Fratta, W., Parmentier, M. Science (1999)
- Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Bilkei-Gorzo, A., Racz, I., Valverde, O., Otto, M., Michel, K., Sastre, M., Sarstre, M., Zimmer, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Steiner, H., Bonner, T.I., Zimmer, A.M., Kitai, S.T., Zimmer, A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens. Hungund, B.L., Szakall, I., Adam, A., Basavarajappa, B.S., Vadasz, C. J. Neurochem. (2003)
- Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. Maccarrone, M., Valverde, O., Barbaccia, M.L., Castañé, A., Maldonado, R., Ledent, C., Parmentier, M., Finazzi-Agrò, A. Eur. J. Neurosci. (2002)
- Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Idris, A.I., van 't Hof, R.J., Greig, I.R., Ridge, S.A., Baker, D., Ross, R.A., Ralston, S.H. Nat. Med. (2005)
- Aberrant cannabinoid signaling impairs oviductal transport of embryos. Wang, H., Guo, Y., Wang, D., Kingsley, P.J., Marnett, L.J., Das, S.K., DuBois, R.N., Dey, S.K. Nat. Med. (2004)
- The endogenous cannabinoid system controls extinction of aversive memories. Marsicano, G., Wotjak, C.T., Azad, S.C., Bisogno, T., Rammes, G., Cascio, M.G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., Di Marzo, V., Lutz, B. Nature (2002)
- Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice. Oka, S., Wakui, J., Ikeda, S., Yanagimoto, S., Kishimoto, S., Gokoh, M., Nasui, M., Sugiura, T. J. Immunol. (2006)
- Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Kimball, E.S., Schneider, C.R., Wallace, N.H., Hornby, P.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. Gardner, B., Zhu, L.X., Sharma, S., Tashkin, D.P., Dubinett, S.M. FASEB J. (2003)
- Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Pacher, P., Bátkai, S., Osei-Hyiaman, D., Offertáler, L., Liu, J., Harvey-White, J., Brassai, A., Járai, Z., Cravatt, B.F., Kunos, G. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Leptin-regulated endocannabinoids are involved in maintaining food intake. Di Marzo, V., Goparaju, S.K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G.I., Palmiter, R.D., Sugiura, T., Kunos, G. Nature (2001)
- Regulation of gonadotropin-releasing hormone secretion by cannabinoids. Gammon, C.M., Freeman, G.M., Xie, W., Xie, W., Petersen, S.L., Wetsel, W.C. Endocrinology (2005)
- Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. Cobellis, G., Cacciola, G., Scarpa, D., Meccariello, R., Chianese, R., Franzoni, M.F., Mackie, K., Pierantoni, R., Fasano, S. Biol. Reprod. (2006)
- Tuning the oviduct to the anandamide tone. Schuel, H. J. Clin. Invest. (2006)
- 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. Zhao, Q., He, Z., Chen, N., Cho, Y.Y., Zhu, F., Lu, C., Ma, W.Y., Bode, A.M., Dong, Z. J. Biol. Chem. (2005)
- The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. Shoemaker, J.L., Seely, K.A., Reed, R.L., Crow, J.P., Prather, P.L. J. Neurochem. (2007)
- The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. Derocq, J.M., Bouaboula, M., Marchand, J., Rinaldi-Carmona, M., Ségui, M., Casellas, P. FEBS Lett. (1998)
- Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. Molina-Holgado, F., Molina-Holgado, E., Guaza, C., Rothwell, N.J. J. Neurosci. Res. (2002)
- Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Lichtman, A.H., Shelton, C.C., Advani, T., Cravatt, B.F. Pain (2004)
- Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Jeong, W.I., Osei-Hyiaman, D., Park, O., Liu, J., Bátkai, S., Mukhopadhyay, P., Horiguchi, N., Harvey-White, J., Marsicano, G., Lutz, B., Gao, B., Kunos, G. Cell Metab. (2008)
- Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. Ortega-Gutiérrez, S., Hawkins, E.G., Viso, A., López-Rodríguez, M.L., Cravatt, B.F. Biochemistry (2004)
- Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Wang, H., Matsumoto, H., Guo, Y., Paria, B.C., Roberts, R.L., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Cannabinoid receptors and their endogenous agonists. Felder, C.C., Glass, M. Annu. Rev. Pharmacol. Toxicol. (1998)
- Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Bisogno, T., Melck, D., De Petrocellis, L., Bobrov MYu, n.u.l.l., Gretskaya, N.M., Bezuglov, V.V., Sitachitta, N., Gerwick, W.H., Di Marzo, V. Biochem. Biophys. Res. Commun. (1998)
- Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain. Hermann, H., Lutz, B. Neurosci. Lett. (2005)
- 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. Kaplan, B.L., Ouyang, Y., Rockwell, C.E., Rao, G.K., Kaminski, N.E. J. Leukoc. Biol. (2005)
- Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus. Derkinderen, P., Ledent, C., Parmentier, M., Girault, J.A. J. Neurochem. (2001)
- Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Egertová, M., Cravatt, B.F., Elphick, M.R. Neuroscience (2003)
- Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation. McCoy, K.L., Matveyeva, M., Carlisle, S.J., Cabral, G.A. J. Pharmacol. Exp. Ther. (1999)
- Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Jo, Y.H., Chen, Y.J., Chua, S.C., Talmage, D.A., Role, L.W. Neuron (2005)
- Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. Lu, T., Newton, C., Perkins, I., Friedman, H., Klein, T.W. Eur. J. Pharmacol. (2006)
- Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system. Bayatti, N., Hermann, H., Lutz, B., Behl, C. Endocrinology (2005)
- Endocannabinoids as physiological regulators of colonic propulsion in mice. Pinto, L., Izzo, A.A., Cascio, M.G., Bisogno, T., Hospodar-Scott, K., Brown, D.R., Mascolo, N., Di Marzo, V., Capasso, F. Gastroenterology (2002)
- The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Paria, B.C., Das, S.K., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Behaviroal, pharmacological, and molecular characterization of an amphibian cannabinoid receptor. Soderstrom, K., Leid, M., Moore, F.L., Murray, T.F. J. Neurochem. (2000)