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Gene Review

UPK1A  -  uroplakin 1A

Homo sapiens

Synonyms: TSPAN21, Tetraspanin-21, Tspan-21, UP1A, UP1a, ...
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Disease relevance of UPK1A


High impact information on UPK1A


Biological context of UPK1A


Anatomical context of UPK1A

  • Although UPIa and UPIb are structurally conserved, only UPIb could exit from the endoplasmic reticulum (ER) and reach the cell surface when expressed alone in 293T cells [7].
  • These results confirm that in human tissues the expression of UPIa and UPII genes is highly specific to urothelium and suggest that the tight differentiation-restricted expression of uroplakin genes in normal urothelium is lost following malignant transformation [8].

Analytical, diagnostic and therapeutic context of UPK1A


  1. Uroplakin gene expression by normal and neoplastic human urothelium. Lobban, E.D., Smith, B.A., Hall, G.D., Harnden, P., Roberts, P., Selby, P.J., Trejdosiewicz, L.K., Southgate, J. Am. J. Pathol. (1998) [Pubmed]
  2. Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. Pak, J., Pu, Y., Zhang, Z.T., Hasty, D.L., Wu, X.R. J. Biol. Chem. (2001) [Pubmed]
  3. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. Xie, B., Zhou, G., Chan, S.Y., Shapiro, E., Kong, X.P., Wu, X.R., Sun, T.T., Costello, C.E. J. Biol. Chem. (2006) [Pubmed]
  4. Human uroplakin Ib in ocular surface epithelium. Adachi, W., Okubo, K., Kinoshita, S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  5. High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma. Kageyama, S., Yoshiki, T., Isono, T., Tanaka, T., Kim, C.J., Yuasa, T., Okada, Y. Jpn. J. Cancer Res. (2002) [Pubmed]
  6. Transcriptional control of the human urothelial-specific gene, uroplakin Ia. Hall, G.D., Weeks, R.J., Olsburgh, J., Southgate, J., Knowles, M.A., Selby, P.J., Chester, J.D. Biochim. Biophys. Acta (2005) [Pubmed]
  7. Integrity of all four transmembrane domains of the tetraspanin uroplakin Ib is required for its exit from the ER. Tu, L., Kong, X.P., Sun, T.T., Kreibich, G. J. Cell. Sci. (2006) [Pubmed]
  8. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. Olsburgh, J., Harnden, P., Weeks, R., Smith, B., Joyce, A., Hall, G., Poulsom, R., Selby, P., Southgate, J. J. Pathol. (2003) [Pubmed]
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