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Gene Review:

ZPBP - zona pellucida binding protein

Homo sapiens

Synonyms: SP38, Sp38, ZPBP1, Zona pellucida-binding protein 1

Katoh, M. et al., Böckers, T.M. et al., Ensslin, M. et al., Mori, T. et al.

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High impact information on ZPBP

The expression of hypothalamic tyrosine hydroxylase in the arcuate nucleus that was determined by immunocytochemistry and by in situ hybridization was also down-regulated in SP18 and SP28 with increasing levels at SP38 [1].
ZPBPL mRNA was co-expressed with ZPBP mRNA in testis, germ cell tumor, and brain medulla [2].
ZPBPL might be implicated in the gamete interaction during fertilization just like ZPBP [2].
ZPBPL (316 aa) and ZPBP (351 aa) proteins, showing 34.8% total amino-acid identity, shared the zona pellucida binding protein homologous (ZPBH) domain with conserved 15 cysteine residues [2].

Biological context of ZPBP

We have also succeeded Sp38 cDNA cloning from cDNA library of porcine testis [3].

Associations of ZPBP with chemical compounds

ZPBPL was a secreted-type glycoprotein with the ZPBH domain, while ZPBP was a type 2 transmembrane protein with the extracellular ZPBH domain [2].

Analytical, diagnostic and therapeutic context of ZPBP

Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins [4].

References

Initial expression of the common alpha-chain in hypophyseal pars tuberalis-specific cells in spontaneous recrudescent hamsters. Böckers, T.M., Bockmann, J., Salem, A., Niklowitz, P., Lerchl, A., Huppertz, M., Wittkowski, W., Kreutz, M.R. Endocrinology (1997) [Pubmed]
Identification and characterization of human ZPBP-like gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
Molecular and immunological approaches to mammalian fertilization. Mori, T., Guo, M.W., Sato, E., Baba, T., Takasaki, S., Mori, E. J. Reprod. Immunol. (2000) [Pubmed]
Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins. Ensslin, M., Vogel, T., Calvete, J.J., Thole, H.H., Schmidtke, J., Matsuda, T., Töpfer-Petersen, E. Biol. Reprod. (1998) [Pubmed]

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