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Gene Review

Idd4  -  insulin dependent diabetes susceptibility 4

Mus musculus

Synonyms: Idd-4
 
 
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Disease relevance of Idd4

 

High impact information on Idd4

 

Biological context of Idd4

 

Anatomical context of Idd4

  • These data, together with the co-localization of type 1 (Idd4) and type 2 (Nidd1n) susceptibility genes on Chr 11, suggest that the intrinsic vulnerability of pancreatic beta cells is determined by a gene or genes on Chr 11, which may also contribute to susceptibility to spontaneous diabetes [9].
  • Only macrophages from the congenic strains containing the Idd4 locus showed IL-12p40 overproduction/expression [7].
  • Previously, we demonstrated that the genetic control of T-cell proliferative unresponsiveness in nonobese diabetic (NOD) mice is linked to Idd4 on mouse chromosome 11 [6].
 

Other interactions of Idd4

References

  1. Crosses of NOD mice with the related NON strain. A polygenic model for IDDM. McAleer, M.A., Reifsnyder, P., Palmer, S.M., Prochazka, M., Love, J.M., Copeman, J.B., Powell, E.E., Rodrigues, N.R., Prins, J.B., Serreze, D.V. Diabetes (1995) [Pubmed]
  2. The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Mock, B.A., Krall, M.M., Byrd, L.G., Chin, H., Barton, C.H., Charles, I., Liew, F.Y., Blackwell, J. Eur. J. Immunogenet. (1994) [Pubmed]
  3. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Todd, J.A., Aitman, T.J., Cornall, R.J., Ghosh, S., Hall, J.R., Hearne, C.M., Knight, A.M., Love, J.M., McAleer, M.A., Prins, J.B. Nature (1991) [Pubmed]
  4. Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. Ivakine, E.A., Gulban, O.M., Mortin-Toth, S.M., Wankiewicz, E., Scott, C., Spurrell, D., Canty, A., Danska, J.S. J. Immunol. (2006) [Pubmed]
  5. The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice. Ivakine, E.A., Mortin-Toth, S.M., Gulban, O.M., Valova, A., Canty, A., Scott, C., Danska, J.S. Diabetes (2006) [Pubmed]
  6. Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Grattan, M., Mi, Q.S., Meagher, C., Delovitch, T.L. Diabetes (2002) [Pubmed]
  7. Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice. Simpson, P.B., Mistry, M.S., Maki, R.A., Yang, W., Schwarz, D.A., Johnson, E.B., Lio, F.M., Alleva, D.G. J. Immunol. (2003) [Pubmed]
  8. Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. Ivakine, E.A., Fox, C.J., Paterson, A.D., Mortin-Toth, S.M., Canty, A., Walton, D.S., Aleksa, K., Ito, S., Danska, J.S. J. Immunol. (2005) [Pubmed]
  9. Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11. Babaya, N., Ikegami, H., Fujisawa, T., Nojima, K., Itoi-Babaya, M., Inoue, K., Ohno, T., Shibata, M., Ogihara, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice. Davoodi-Semiromi, A., Laloraya, M., Kumar, G.P., Purohit, S., Jha, R.K., She, J.X. J. Biol. Chem. (2004) [Pubmed]
  11. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. Butterfield, R.J., Sudweeks, J.D., Blankenhorn, E.P., Korngold, R., Marini, J.C., Todd, J.A., Roper, R.J., Teuscher, C. J. Immunol. (1998) [Pubmed]
  12. Mapping of the gene for inducible nitric oxide (NO) synthase of mouse macrophages to chromosome 11, close to Evi-2, nu, and Idd-4. Jenkins, N.A., Rothe, H., Gilbert, D.J., Copeland, N.G., Kolb, H. Genomics (1994) [Pubmed]
 
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