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Gene Review:

Igkj4 - immunoglobulin kappa joining 4

Mus musculus

Synonyms: Igk-J4

Hawley, R.G. et al., Ozawa, M. et al., Hawley, R.G. et al., Sakano, H. et al., Wu, L.C. et al., et al.

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High impact information on Igk-J4

The entire nucleotide sequence of a 1.7-kilobase embryonic DNA fragment containing five joining (J) DNA segments for mouse immunoglobulin kappa chain gene has been determined [1].
Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes [2].
Circular DNAs excised by immunoglobulin kappa chain gene rearrangements were cloned and characterized [3].
HHAM viruses containing the mouse c-myc gene under the control of immunoglobulin kappa chain gene regulatory elements, along with a selectable gene (neo) driven by a weak promoter (tk), were stably transmitted to cultured mouse B cells [4].
Multiple-alphabet amino acid sequence comparisons of the immunoglobulin kappa-chain constant domain [5].

Biological context of Igk-J4

Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA [6].
We conducted a search for direct repeats in the mouse immunoglobulin kappa-chain genes [7].
Rc is a DNA binding protein with dual specificities for the V(D)J recombination signal sequences and for the B motif of the immunoglobulin kappa chain gene enhancer [8].
A nonfunctional immunoglobulin kappa-chain gene previously shown to contain intracisternal A-particle (IAP) sequences within one of its introns was further characterized by DNA and RNA blot analysis [9].

Anatomical context of Igk-J4

Sequences related to immunoglobulin kappa chain messenger RNA in T cells [10].
Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization [11].

Associations of Igk-J4 with chemical compounds

Sequence homology to variable domain of immunoglobulin kappa chain has been detected in a domain; homologous amino acids near cysteine residues are those conserved in many members of the immunoglobulin gene superfamily [12].

Analytical, diagnostic and therapeutic context of Igk-J4

Molecular cloning of seven mouse immunoglobulin kappa chain messenger ribonucleic acids [13].

References

Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Sakano, H., Hüppi, K., Heinrich, G., Tonegawa, S. Nature (1979) [Pubmed]
Antibody diversity. Seidman, J.G., Leder, A., Nau, M., Norman, B., Leder, P. Science (1978) [Pubmed]
Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles. Harada, K., Yamagishi, H. J. Exp. Med. (1991) [Pubmed]
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells. Hawley, R.G., Covarrubias, L., Hawley, T., Mintz, B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
Multiple-alphabet amino acid sequence comparisons of the immunoglobulin kappa-chain constant domain. Karlin, S., Ghandour, G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA. Storb, U., Marvin, S. J. Immunol. (1976) [Pubmed]
Two-dimensional graphic analysis of DNA sequence homologies. Harr, R., Hagblom, P., Gustafsson, P. Nucleic Acids Res. (1982) [Pubmed]
The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins. Wu, L.C., Liu, Y., Strandtmann, J., Mak, C.H., Lee, B., Li, Z., Yu, C.Y. Genomics (1996) [Pubmed]
Transposition of intracisternal A-particle genes in mouse hybridomas. Hawley, R.G., Trimble, W.S., Shulman, M.J., Hozumi, N. Journal of cellular physiology. Supplement. (1984) [Pubmed]
Sequences related to immunoglobulin kappa chain messenger RNA in T cells. Storb, U., Hager, L., Putnam, D., Buck, L., Farin, F., Clagett, J. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization. Storb, U. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. Ozawa, M., Huang, R.P., Furukawa, T., Muramatsu, T. J. Biol. Chem. (1988) [Pubmed]
Molecular cloning of seven mouse immunoglobulin kappa chain messenger ribonucleic acids. Gough, N.M., Webb, E.A., Cory, S., Adams, J.M. Biochemistry (1980) [Pubmed]

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