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Gene Review

NUPL2  -  nucleoporin like 2

Homo sapiens

Synonyms: CG1, H_RG271G13.9, NLP-1, NLP_1, NUP42 homolog, ...
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Disease relevance of NUPL2

  • An interaction between HIV-1 Vpr and the human nucleoporin CG1 (hCG1) was revealed in the yeast two-hybrid system, and then confirmed both in vitro and in transfected cells [1].
  • NLP-1 represents a lead compound for intercalating 2-nitroimidazoles with selective toxicity for hypoxic cells [2].

High impact information on NUPL2

  • Using a nuclear import assay based on digitonin-permeabilized cells, we demonstrate that hCG1 participates in the docking of Vpr at the nuclear envelope [1].
  • In addition, gene expression analysis and wheat germ agglutinin chromatography experiments suggested that NLP-1 is an ubiquitous O-glycosylated nuclear protein [3].
  • This protein has features found in nucleoporins including many phenylalanine-glycine repeats, a very high serine content, a putative zinc finger, and a coiled-coil domain; we thus called it NLP-1 (nucleoporin-like protein 1) [3].
  • CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif [4].
  • Mutation analysis of the CG1 gene in DFNA5 patients, however, could not reveal a disease-causing mutation [5].

Chemical compound and disease context of NUPL2

  • At a concentration of 0.5 mM, NLP-1 is 8 times more toxic to hypoxic than aerobic cells at 37 degrees C. This concentration is 40 times less than the concentration of misonidazole, a non-intercalating 2-nitroimidazole, required for the same degree of hypoxic cell toxicity [2].

Anatomical context of NUPL2

  • We cloned a novel candidate gene (CG1, candidate gene 1), which is expressed in human fetal cochlea, from the DFNA5 candidate region [5].

Associations of NUPL2 with chemical compounds


  1. Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. Le Rouzic, E., Mousnier, A., Rustum, C., Stutz, F., Hallberg, E., Dargemont, C., Benichou, S. J. Biol. Chem. (2002) [Pubmed]
  2. NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Panicucci, R., Heal, R., Laderoute, K., Cowan, D., McClelland, R.A., Rauth, A.M. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  3. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. Farjot, G., Sergeant, A., Mikaélian, I. J. Biol. Chem. (1999) [Pubmed]
  4. A smart magnetic resonance contrast agent for selective copper sensing. Que, E.L., Chang, C.J. J. Am. Chem. Soc. (2006) [Pubmed]
  5. Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea. Van Laer, L., Van Camp, G., van Zuijlen, D., Green, E.D., Verstreken, M., Schatteman, I., Van de Heyning, P., Balemans, W., Coucke, P., Greinwald, J.H., Smith, R.J., Huizing, E., Willems, P. Eur. J. Hum. Genet. (1997) [Pubmed]
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