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Chemical Compound Review

PHENANTHRIDINE     phenanthridine

Synonyms: SureCN8666, CHEMBL504941, CCRIS 1234, AG-E-66546, ACMC-209g04, ...
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Disease relevance of phenanthridine


High impact information on phenanthridine


Biological context of phenanthridine


Anatomical context of phenanthridine


Associations of phenanthridine with other chemical compounds


Gene context of phenanthridine

  • The new selective D-1 agonist CY208-243 ((-)-4,6,6a,7,8,12b-hexahydro-7-methyl-indolo [4,3-ab] phenanthridine), unlike SKF38393, produced some increase in activity 4 h after reserpine, but much greater activity was seen 1 and 3 days after reserpine [19].
  • 3,4-Benzoquinoline was the only agent to significantly increase microsomal epoxide hydrolase activity (2,3-fold) [20].

Analytical, diagnostic and therapeutic context of phenanthridine

  • The binding of phenanthridine dyes to triplex poly(dT)*poly(dA).poly(dT) and its precursor duplex poly(dA).poly(dT) is characterized using linear dichroism and circular dichroism spectroscopy, and thermal denaturation [21].


  1. Metabolism of phenanthridine to phenanthridone by rat lung and liver microsomes after induction with benzo[a]pyrene and Aroclor. Benson, J.M., Royer, R.E., Galvin, J.B., Shimizu, R.W. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  2. Photochemical and photobiological studies with acridine and phenanthridine hydroperoxides in cell-free DNA. Adam, W., Groer, P., Mielke, K., Saha-Möller, C.R., Hutterer, R., Kiefer, W., Nagel, V., Schneider, F.W., Ballmaier, D., Schleger, Y., Epe, B. Photochem. Photobiol. (1997) [Pubmed]
  3. Degradation of phenanthrene-analogue azaarenes by Mycobacterium gilvum strain LB307T under aerobic conditions. Willumsen, P.A., Nielsen, J.K., Karlson, U. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  4. Phototoxicity of azaarene isomers to the marine flagellate Dunaliella tertiolecta. Wiegman, S., van Vlaardingen, P.L., Bleeker, E.A., de Voogt, P., Kraak, M.H. Environ. Toxicol. Chem. (2001) [Pubmed]
  5. Estimation of kinetic parameter for the biotransformation of three-ring azaarenes by the phenanthrene-degrading strain Sphingomonas sp. LH128. van Herwijnen, R., de Graaf, C., Govers, H.A., Parsons, J.R. Environ. Toxicol. Chem. (2004) [Pubmed]
  6. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. Terao, M., Kurosaki, M., Saltini, G., Demontis, S., Marini, M., Salmona, M., Garattini, E. J. Biol. Chem. (2000) [Pubmed]
  7. NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Panicucci, R., Heal, R., Laderoute, K., Cowan, D., McClelland, R.A., Rauth, A.M. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  8. Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L. Int. J. Oncol. (2003) [Pubmed]
  9. DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation. Buchko, G.W., Weinfeld, M. Radiat. Res. (2002) [Pubmed]
  10. Metabolites of phenanthridine formed by rat liver homogenate. LaVoie, E.J., Adams, E.A., Shigematsu, A., Hoffmann, D. Drug Metab. Dispos. (1985) [Pubmed]
  11. A35512, a complex of new antibacterial antibiotics produced by Streptomyces candidus. II. Chemical studies on A35512B. Debono, M., Molloy, R.M., Barnhart, M., Dorman, D.E. J. Antibiot. (1980) [Pubmed]
  12. Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase. Saieed, P., Reza, R.M., Abbas, D., Seyyedvali, R., Aliasghar, H. Chem. Pharm. Bull. (2006) [Pubmed]
  13. Toxic effects and oxidative stress in higher plants exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivatives. Paková, V., Hilscherová, K., Feldmannová, M., Bláha, L. Environ. Toxicol. Chem. (2006) [Pubmed]
  14. A comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy. Dougherty, G. Int. J. Biochem. (1982) [Pubmed]
  15. Multicellular membranes as an in vitro model for extravascular diffusion in tumours. Cowan, D.S., Hicks, K.O., Wilson, W.R. Br. J. Cancer Suppl. (1996) [Pubmed]
  16. The binding of anti-DNA antibodies as measured fluorometrically by ethidium bromide. Shepherd, J.D., Fritzler, M.J., Watson, J.I., van de Sande, J.H. J. Rheumatol. (1978) [Pubmed]
  17. Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats. LaVoie, E.J., Dolan, S., Little, P., Wang, C.X., Sugie, S., Rivenson, A. Food Chem. Toxicol. (1988) [Pubmed]
  18. Chemical cross-linking of ethidium to DNA by glyoxal. Leng, F., Graves, D., Chaires, J.B. Biochim. Biophys. Acta (1998) [Pubmed]
  19. Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse. Ross, S.B., Jackson, D.M., Wallis, E.M., Edwards, S.R. Naunyn Schmiedebergs Arch. Pharmacol. (1988) [Pubmed]
  20. Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic nitrogen. Le, H.T., Lamb, J.G., Franklin, M.R. J. Biochem. Toxicol. (1996) [Pubmed]
  21. Intercalative interactions of ethidium dyes with triplex structures. Tuite, E., Nordén, B. Bioorg. Med. Chem. (1995) [Pubmed]
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