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Gene Review

KLF8  -  Kruppel-like factor 8

Homo sapiens

Synonyms: BKLF3, Basic krueppel-like factor 3, DXS741, Krueppel-like factor 8, ZNF741, ...
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Psychiatry related information on KLF8

  • Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation [1].

Disease relevance of KLF8

  • This work identifies KLF8 as a novel EMT-regulating transcription factor that opens a new avenue in EMT research and suggests an important role for KLF8 in human breast cancer invasion and metastasis [2].
  • Taken together, our data suggest that FAK induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signaling pathway, leading to the activation of KLF8 promoter by Sp1 [3].

High impact information on KLF8


Biological context of KLF8

  • These results establish KLF8 as a CACCC-box binding protein that associates with CtBP and represses transcription [7].
  • We demonstrate that the zinc fingers of KLF8 recognize CACCC elements in DNA and that full-length KLF8 can repress a CACCC-dependent promoter [7].
  • Mutation screening of probands from 20 unrelated XLMR families linked to the proximal short arm of the human X chromosome failed to show any mutation in the coding region of the KLF8 gene [1].
  • We have mapped the X chromosome breakpoint to a 21 kb DNA fragment upstream of the first exon of the KLF8 (ZNF741) gene in Xp11.21 [1].
  • YAC-derived cosmids were used to clone and map the IP1 breakpoints to a 180-kb interval that was flanked by DNA markers DXS705 and DXS741 [8].

Anatomical context of KLF8

  • In co-transfection assays in K562 cells, it was demonstrated that KLF2, 5 and 13 positively regulate, and KLF8 negatively regulates, the gamma-globin gene through the CACCC promoter element [9].

Associations of KLF8 with chemical compounds

  • Lysine 67 to arginine mutation strongly enhanced activity of KLF8 as a repressor or activator to its physiological target promoters and as an inducer of the G(1) cell cycle progression [5].


  1. Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. Lossi, A.M., Laugier-Anfossi, F., Depetris, D., Gecz, J., Gedeon, A., Kooy, F., Schwartz, C., Mattei, M.G., Croquette, M.F., Villard, L. J. Med. Genet. (2002) [Pubmed]
  2. Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang, X., Zheng, M., Liu, G., Xia, W., McKeown-Longo, P.J., Hung, M.C., Zhao, J. Cancer Res. (2007) [Pubmed]
  3. Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang, X., Urvalek, A.M., Liu, J., Zhao, J. J. Biol. Chem. (2008) [Pubmed]
  4. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Zhao, J., Bian, Z.C., Yee, K., Chen, B.P., Chien, S., Guan, J.L. Mol. Cell (2003) [Pubmed]
  5. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. Wei, H., Wang, X., Gan, B., Urvalek, A.M., Melkoumian, Z.K., Guan, J.L., Zhao, J. J. Biol. Chem. (2006) [Pubmed]
  6. KLF8 transcription factor participates in oncogenic transformation. Wang, X., Zhao, J. Oncogene (2007) [Pubmed]
  7. Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. van Vliet, J., Turner, J., Crossley, M. Nucleic Acids Res. (2000) [Pubmed]
  8. Cosmids map two incontinentia pigmenti type 1 (IP1) translocation breakpoints to a 180-kb region within a 1.2-Mb YAC contig. Gorski, J.L., Bialecki, M.D., McDonald, M.T., Massa, H.F., Trask, B.J., Burright, E.N. Genomics (1996) [Pubmed]
  9. A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element. Zhang, P., Basu, P., Redmond, L.C., Morris, P.E., Rupon, J.W., Ginder, G.D., Lloyd, J.A. Blood Cells Mol. Dis. (2005) [Pubmed]
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