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Gene Review

CGB1  -  chorionic gonadotropin, beta polypeptide 1

Homo sapiens

Synonyms: Choriogonadotropin subunit beta variant 1
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Disease relevance of CGB1

  • To better understand the dysregulation of the CGB/LHB gene cluster in breast cancer, we have developed real-time quantitative RT-PCR assays to analyze each subgroup of genes (the overall CGB genes, CGB1 and B2 together, and LHB alone) in 17 unilateral invasive primary breast tumor RNAs [1].

High impact information on CGB1

  • In silico prediction of putative transcription factor binding sites supports the hypothesis that CGB1 and CGB2 gene products are expressed in, and may contribute to, implantation and placental development [2].
  • The 5'-upstream region of CGB1/2 contains most of the promoter sequence of hCGbeta plus a novel region proximal to the putative transcription start site [2].
  • The additional phenotypes of cgb1 mutants, including severe loss of virulence on maize and of the ability to produce conidia, are consistent with CGB1 being unique in the genome [3].
  • The effects of mutating a third signal transduction pathway gene, CGB1, encoding the Gbeta subunit, are reported here [3].
  • CGB1 is the sole Gbeta subunit-encoding gene in the genome of this organism. cgb1 mutants are nearly wild type in vegetative growth rate; however, Cgb1 is required for appressorium formation, female fertility, conidiation, regulation of hyphal pigmentation, and wild-type virulence on maize [3].

Other interactions of CGB1

  • The function of two additional gene copies, CGB1 and CGB2, is still unknown [4].


  1. Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays. Giovangrandi, Y., Parfait, B., Asheuer, M., Olivi, M., Lidereau, R., Vidaud, M., Bièche, I. Cancer Lett. (2001) [Pubmed]
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. Hallast, P., Rull, K., Laan, M. Mol. Cell. Endocrinol. (2007) [Pubmed]
  3. G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis. Ganem, S., Lu, S.W., Lee, B.N., Chou, D.Y., Hadar, R., Turgeon, B.G., Horwitz, B.A. Eukaryotic Cell (2004) [Pubmed]
  4. Expression of beta-subunit of HCG genes during normal and failed pregnancy. Rull, K., Laan, M. Hum. Reprod. (2005) [Pubmed]
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