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Gene Review

LHB  -  luteinizing hormone beta polypeptide

Homo sapiens

Synonyms: CGB4, LH-B, LSH-B, LSH-beta, Luteinizing hormone subunit beta, ...
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Disease relevance of LHB


High impact information on LHB


Chemical compound and disease context of LHB


Biological context of LHB

  • The six genes of the human chorionic gonadotropin beta subunit (CGB) and the gene of the luteinizing hormone beta subunit (LHB) are located in a cluster that spans 50 kb on chromosome 19q13 [1].
  • Direct sequencing was performed for a 661 bp promoter region from -8 to -668 bp of LHB, revealing homozygosity for eight nucleotide substitutions (-238A>G, -276G>A, -489C>A, -490T>A, -504T>A, -506T>C, -525T>G, and -552C>T) that are identical to those found in the hyperfunctional promoter [12].
  • In the LHB/CGB region, high sequence diversity, concentration of gene-conversion acceptor sites, and strong LD colocalize with peripheral genes, whereas central loci are characterized by lower variation, gene-conversion donor activity, and breakdown of LD between close markers [6].
  • This study subsequently aimed to examine the role of Prop-1 in the gene expression of two other porcine gonadotropin subunits, pituitary glycoprotein hormone alpha subunit (alphaGSU), and luteinizing hormone beta subunit (LHbeta) [13].
  • The NZW and Dutch rabbit LHB coding sequences are 426bp long, and their G+C contents are higher (>73%) than those of other mammalian LHBs (<70%) [14].

Anatomical context of LHB


Associations of LHB with chemical compounds

  • To shed light on these issues, we have re-sequenced the human Luteinizing Hormone/Chorionic Gonadotropin beta (LHB/CGB) cluster (19q13.32) of three population samples (Estonians, Mandenka, and Han) [6].
  • In addition, a significant positive correlation was found between serum testosterone levels and LH B/I ratios in the impotent men (r = 0.45; P = 0.029) [16].
  • Measurements of basal and stimulated gonadotropins (immunoactive LH, LH-I; bioactive LH, LH-B; immunoactive FSH, FSH-I) and E2 were obtained before and after administration of clomiphene citrate [17].

Other interactions of LHB


Analytical, diagnostic and therapeutic context of LHB

  • Northern blot analysis indicated that the approximately 600-nt mRNA encoding JW LHB is slightly longer than the LHB mRNAs of the other two breeds [14].


  1. Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays. Giovangrandi, Y., Parfait, B., Asheuer, M., Olivi, M., Lidereau, R., Vidaud, M., Bièche, I. Cancer Lett. (2001) [Pubmed]
  2. Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Takahashi, K., Kurioka, H., Ozaki, T., Kanasaki, H., Kohsaka, M., Miyazaki, K., Karino, K. Hum. Reprod. (1998) [Pubmed]
  3. Identification of gonadotroph adenomas in men with clinically nonfunctioning adenomas by the luteinizing hormone beta subunit response to thyrotropin-releasing hormone. Daneshdoost, L., Gennarelli, T.A., Bashey, H.M., Savino, P.J., Sergott, R.C., Bosley, T.M., Snyder, P.J. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  4. Abnormal response of luteinizing hormone beta subunit to thyrotrophin-releasing hormone in patients with non-functioning pituitary adenoma. Gil-del-Alamo, P., Pettersson, K.S., Saccomanno, K., Spada, A., Faglia, G., Beck-Peccoz, P. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  5. Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. Lee, S., Kim, N.K., Kim, H.J., Lee, S.H., Jeong, H.J., Cha, K.Y. Fertil. Steril. (2003) [Pubmed]
  6. Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster. Hallast, P., Nagirnaja, L., Margus, T., Laan, M. Genome Res. (2005) [Pubmed]
  7. p300 regulates the synergy of steroidogenic factor-1 and early growth response-1 in activating luteinizing hormone-beta subunit gene. Mouillet, J.F., Sonnenberg-Hirche, C., Yan, X., Sadovsky, Y. J. Biol. Chem. (2004) [Pubmed]
  8. Multiple mechanisms for Pitx-1 transactivation of a luteinizing hormone beta subunit gene. Melamed, P., Koh, M., Preklathan, P., Bei, L., Hew, C. J. Biol. Chem. (2002) [Pubmed]
  9. Free luteinizing-hormone beta-subunit in normal subjects and patients with pituitary adenomas. Chanson, P., Pantel, J., Young, J., Couzinet, B., Bidart, J.M., Schaison, G. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  10. Varicocele in prepubertal boys. Evaluation of clinical Doppler and hormonal findings. Fideleff, H.L., Boquete, H., Ruibal, G., Suärez, M., Sobrado, P., Zanchetti, F., Perco, M., Holland, M. Medicina (B Aires) (1996) [Pubmed]
  11. Frequency of the allelic variant (Trp8Arg/Ile15Thr) of the luteinizing hormone gene in a Brazilian cohort of healthy subjects and in patients with hypogonadotropic hypogonadism. Berger, K., Billerbeck, A.E., Costa, E.M., Carvalho, L.S., Arnhold, I.J., Mendonca, B.B. Clinics (São Paulo, Brazil) (2005) [Pubmed]
  12. Association of common LH variant with hyperfunctional promoter in a Japanese infertile woman. Liu, S., Ogata, T., Maruyama, T., Yoshimura, Y., Ishizuka, B. Endocr. J. (2005) [Pubmed]
  13. Pituitary transcription factor Prop-1 stimulates porcine pituitary glycoprotein hormone {alpha} subunit gene expression. Sato, T., Kitahara, K., Susa, T., Kato, T., Kato, Y. J. Mol. Endocrinol. (2006) [Pubmed]
  14. Analyses of the cDNA and genomic DNA sequences encoding the luteinizing hormone beta-subunit precursor protein in the rabbit. Suzuki, O., Koura, M., Noguchi, Y., Takano, K., Uchio-Yamada, K., Matsuda, J. Gen. Comp. Endocrinol. (2007) [Pubmed]
  15. Identification of human luteinizing hormone, follicle-stimulating hormone, luteinizing hormone beta-subunit and gonadotrophin alpha-subunit in foetal and adult pituitary glands. Hagen, C., McNeilly, A.S. J. Endocrinol. (1975) [Pubmed]
  16. Low serum bioactive luteinizing hormone in nonorganic male impotence: possible relationship with altered gonadotropin-releasing hormone pulsatility. Fabbri, A., Jannini, E.A., Ulisse, S., Gnessi, L., Moretti, C., Frajese, G., Isidori, A. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  17. Response to clomiphene citrate challenge test in normal women through perimenopause. Gindoff, P.R., Schmidt, P.J., Rubinow, D.R. Gynecol. Obstet. Invest. (1997) [Pubmed]
  18. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Elter, K., Erel, C.T., Cine, N., Ozbek, U., Hacihanefioglu, B., Ertungealp, E. Fertil. Steril. (1999) [Pubmed]
  19. Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3. Parfait, B., Giovangrandi, Y., Asheuer, M., Laurendeau, I., Olivi, M., Vodovar, N., Vidaud, D., Vidaud, M., Bièche, I. Ann. Genet. (2000) [Pubmed]
  20. Increased prevalence of luteinizing hormone beta-subunit variant in patients with premature ovarian failure. Takahashi, K., Ozaki, T., Okada, M., Kurioka, H., Kanasaki, H., Miyazaki, K. Fertil. Steril. (1999) [Pubmed]
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