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Gene Review

cx27.5  -  connexin 27.5

Danio rerio

Synonyms: SO:0000704
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High impact information on cx27.5

  • Gap junctions are composed of connexin (Cx) proteins and mediate intercellular communication required for many developmental and physiological processes [1].
  • By combining in situ hybridization with Laser Capture Microdissection and RT-PCR, we found that this novel fish connexin is expressed in horizontal cells in the inner nuclear layer of the retina [2].
  • This report identifies the first gene identification for a fin length mutation (sof) as well as the first connexin mutations in zebrafish, and therefore reveals a critical role for local cell-cell communication in the regulation of bone size and growth [3].
  • We found evidence for duplication events in all genomes, as well as evidence for recent tandem duplication events in the zebrafish, indicating that the complexity of the connexin family is growing [4].
  • The protein encoded by this open reading frame contains 391 amino acids, with a predicted molecular weight of 44.1 kDa and a typical connexin transmembrane topology [5].

Anatomical context of cx27.5

  • Complete connexin gene families have been identified from human (20) and mouse (19), revealing significant diversity in gap junction channels [4].

Other interactions of cx27.5


Analytical, diagnostic and therapeutic context of cx27.5


  1. Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos. Cheng, S., Shakespeare, T., Mui, R., White, T.W., Valdimarsson, G. J. Biol. Chem. (2004) [Pubmed]
  2. Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina. Zoidl, G., Bruzzone, R., Weickert, S., Kremer, M., Zoidl, C., Mitropoulou, G., Srinivas, M., Spray, D.C., Dermietzel, R. J. Biol. Chem. (2004) [Pubmed]
  3. Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Iovine, M.K., Higgins, E.P., Hindes, A., Coblitz, B., Johnson, S.L. Dev. Biol. (2005) [Pubmed]
  4. Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Eastman, S.D., Chen, T.H., Falk, M.M., Mendelson, T.C., Iovine, M.K. Genomics (2006) [Pubmed]
  5. Molecular cloning, expression analysis, and functional characterization of connexin44.1: a zebrafish lens gap junction protein. Cason, N., White, T.W., Cheng, S., Goodenough, D.A., Valdimarsson, G. Dev. Dyn. (2001) [Pubmed]
  6. Molecular and functional diversity of neural connexins in the retina. Dermietzel, R., Kremer, M., Paputsoglu, G., Stang, A., Skerrett, I.M., Gomes, D., Srinivas, M., Janssen-Bienhold, U., Weiler, R., Nicholson, B.J., Bruzzone, R., Spray, D.C. J. Neurosci. (2000) [Pubmed]
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