High impact information on cx27.5

• Gap junctions are composed of connexin (Cx) proteins and mediate intercellular communication required for many developmental and physiological processes [1].
• By combining in situ hybridization with Laser Capture Microdissection and RT-PCR, we found that this novel fish connexin is expressed in horizontal cells in the inner nuclear layer of the retina [2].
• This report identifies the first gene identification for a fin length mutation (sof) as well as the first connexin mutations in zebrafish, and therefore reveals a critical role for local cell-cell communication in the regulation of bone size and growth [3].
• We found evidence for duplication events in all genomes, as well as evidence for recent tandem duplication events in the zebrafish, indicating that the complexity of the connexin family is growing [4].
• The protein encoded by this open reading frame contains 391 amino acids, with a predicted molecular weight of 44.1 kDa and a typical connexin transmembrane topology [5].

Anatomical context of cx27.5

• Complete connexin gene families have been identified from human (20) and mouse (19), revealing significant diversity in gap junction channels [4].

Other interactions of cx27.5

• Three new Cxs, designated as zebrafish Cx27.5 (zfCx27.5), zfCx44.1, and zfCx55.5, and the carp ortholog of mammalian Cx43 were cloned [6].

Analytical, diagnostic and therapeutic context of cx27.5

• Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina [2].

References