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Chemical Compound Review

Brigade     (2-methyl-3-phenyl- phenyl)methyl 3-[(Z)-2...

Synonyms: Talstar, BIFENTHRIN, Biphenthrin, CHEMBL68000, HSDB 6568, ...
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Disease relevance of Biphenthrin

  • We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment [1].
  • Hepatitis B virus DNA was measured frequently with the Digene Hybrid Capture II test and the Roche PCR assay.RESULTS: The description of viral decline in our closely monitored patients by means of the mixed-effects approach with both the bi-phasic model and a piecewise linear regression model resulted in a good fit [2].
  • HIV antibody status was determined by ELISA of oral mucosal specimens, and HPV DNA in the genital tract was identified by hybridization of cervical scrapes with probe B of Hybrid Capture II [3].
  • A multivalent HPV hybridization probe, Digene Hybrid Capture II (Gaithersburg, MD), which recognizes high-risk types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, was used to determine the HPV infection status of the cytologic specimens, and the endoscopic biopsies were used to classify each subject's esophageal disease [4].
  • Evaluation of the Digene Hybrid Capture System for detection and quantitation of human cytomegalovirus viremia in human immunodeficiency virus-infected patients [5].

Psychiatry related information on Biphenthrin

  • We carried out a brief longitudinal mental health screen of 254 members of the UK's Air Assault Brigade before and after deployment to Iraq last year [6].

High impact information on Biphenthrin

  • METHODS: Cervical samples from 2944 previously unscreened South African women aged 35-65 years were tested for high-risk types of HPV with the use of the Hybrid Capture I (HCI) assay [7].
  • Before HCT, basic core promoter (T(1762)/A(1764)) and precore (A(1896)) HBV variants were determined in HBsAg-positive and HBV DNA-positive (by polymerase chain reaction assay) patients by direct sequencing and serum HBV DNA quantitation using the Digene Hybrid Capture II assay [8].
  • Physical interactions between genetic elements located throughout the genome play important roles in gene regulation and can be identified with the Chromosome Conformation Capture (3C) methodology [9].
  • By combining in situ hybridization with Laser Capture Microdissection and RT-PCR, we found that this novel fish connexin is expressed in horizontal cells in the inner nuclear layer of the retina [10].
  • Several types of HPV DNA tests are now available, including Southern blots, dot blots, in situ hybridization, polymerase chain reaction, and solution hybridization (Hybrid Capture assay) [11].

Chemical compound and disease context of Biphenthrin


Biological context of Biphenthrin

  • In a subset of these samples, HPV FISH demonstrated higher sensitivity and specificity than Hybrid Capture (Digene, Gaithersburg, MD) for high-risk genotypes [16].
  • Comparison of the Murex Hybrid Capture CMV DNA (v2.0) assay and the pp65 CMV antigenemia test for the detection and quantitation of CMV in blood samples from immunocompromised patients [17].
  • In the case of organisms for which standard methods such as Capture/Mark/Recapture cannot be used, population genetics provide a straightforward approach to delimitate populations [18].
  • [(1990): Journal of Clinical Microbiology 25:2739-2743] were of intermediate sensitivity (i.e., produced positive signals from samples containing 250 and 2,500 HPV-16 genoms/reaction, respectively) and Hybrid Capture could detect just 50,000 HPV-16 genomes/reaction [19].
  • All patients were investigated by a new PAP smear, histology, and two commercially available HPV tests: Hybrid Capture II (Digene, Gaithersburg, MD) and the Pre Tect HPV-Proofer (NorChip AS) [20].

Anatomical context of Biphenthrin


Associations of Biphenthrin with other chemical compounds

  • Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements [9].
  • Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy [25].
  • The efficacy of reprocessing unsatisfactory cervicovaginal ThinPrep specimens with and without glacial acetic acid: effect on Hybrid Capture II human papillomavirus testing and clinical follow-up [26].
  • Detection techniques include Hybrid Capture (Digene, Silver Springs, MD) and PCR [27].
  • STUDY DESIGN: The HPV DNA Hybrid Capture II (Digene/Abbott, Maidenhead) was evaluated on 110 consenting women with mild dyskaryosis and 23 women with persistent borderline changes, who were referred for colposcopy between May and November 2001 [28].

Gene context of Biphenthrin

  • We show that a new splice variant of cyclin E found in tumor cells isolated by the Splice Capture strategy, named Delta48, activates CDK2 more robustly than full-length cyclin E when assayed from transiently transfected cells with the natural substrate GST-Rb [29].
  • Splice Capture enumerated the relative abundance of known forms of cyclin E mRNA and easily discovered new splice variants in both normal and tumor cells [29].
  • RESULTS: Capture enzyme-linked immunosorbent assays with mouse anti-soluble HLA-G showed that soluble HLA-G was present at all stages of gestation and that levels of soluble HLA-G were statistically significantly higher in serum samples from pregnant women than in serum samples from nonpregnant women [30].
  • IL-1beta, IL-6, TNF-alpha, and PGE(2) levels were measured in the culture medium using ELISA Capture or EIA kits [31].
  • The role of A/G polymorphism at nucleotide -1082 in the interleukin-10 (IL-10) promoter was assessed by following the disease course of 253 patients who had had a routine diagnostic Hybrid Capture human papillomavirus (HPV) test because of cytologic or colposcopic abnormalities of the uterine cervix [32].

Analytical, diagnostic and therapeutic context of Biphenthrin

  • PARTICIPANTS: Of 11742 randomly selected women, 8554 nonpregnant, sexually active women without hysterectomies underwent initial HPV DNA testing using the original Hybrid Capture Tube test; a stratified subsample of 1119 specimens was retested using the more analytically sensitive second generation assay, the Hybrid Capture II test [33].
  • METHODS: Ninety-two participants--53% Latino, 36% African American, and 40% without a history of receptive anal intercourse (RAI)--were evaluated with a behavioral questionnaire, liquid-based anal cytological testing, Hybrid Capture 2 human papillomavirus (HPV) DNA assay and polymerase chain reaction, and anal colposcopy with biopsy of lesions [34].
  • METHODS: Capture probes were immobilized either passively or covalently on the optically coated surface of the biosensor [35].
  • The sensitivities of cervical neoplasia detection using the fluid-based Papanicolaou test (73.9%) and Hybrid Capture II (76.3%, P=0.55) were not significantly different [36].
  • These data allow the direct comparison of viral load values between the Amplicor and Hybrid Capture tests [37].


  1. Viral load of human papillomavirus and risk of CIN3 or cervical cancer. Lorincz, A.T., Castle, P.E., Sherman, M.E., Scott, D.R., Glass, A.G., Wacholder, S., Rush, B.B., Gravitt, P.E., Schussler, J.E., Schiffman, M. Lancet (2002) [Pubmed]
  2. The influence of baseline characteristics on viral dynamic parameters in chronic hepatitis B patients treated with lamivudine. Wolters, L.M., Hansen, B.E., Niesters, H.G., Levi-Drummer, R.S., Neumann, A.U., Schalm, S.W., de Man, R.A. J. Hepatol. (2002) [Pubmed]
  3. HPV-based cervical cancer screening in a population at high risk for HIV infection. Womack, S.D., Chirenje, Z.M., Gaffikin, L., Blumenthal, P.D., McGrath, J.A., Chipato, T., Ngwalle, S., Munjoma, M., Shah, K.V. Int. J. Cancer (2000) [Pubmed]
  4. No association between HPV infection and the neoplastic progression of esophageal squamous cell carcinoma: result from a cross-sectional study in a high-risk region of China. Gao, G.F., Roth, M.J., Wei, W.Q., Abnet, C.C., Chen, F., Lu, N., Zhao, F.H., Li, X.Q., Wang, G.Q., Taylor, P.R., Pan, Q.J., Chen, W., Dawsey, S.M., Qiao, Y.L. Int. J. Cancer (2006) [Pubmed]
  5. Evaluation of the Digene Hybrid Capture System for detection and quantitation of human cytomegalovirus viremia in human immunodeficiency virus-infected patients. Mazzulli, T., Wood, S., Chua, R., Walmsley, S. J. Clin. Microbiol. (1996) [Pubmed]
  6. Going to war does not have to hurt: preliminary findings from the British deployment to Iraq. Hughes, J.H., Cameron, F., Eldridge, R., Devon, M., Wessely, S., Greenberg, N. The British journal of psychiatry : the journal of mental science. (2005) [Pubmed]
  7. Human papillomavirus DNA testing for cervical cancer screening in low-resource settings. Kuhn, L., Denny, L., Pollack, A., Lorincz, A., Richart, R.M., Wright, T.C. J. Natl. Cancer Inst. (2000) [Pubmed]
  8. High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantation. Lau, G.K., Leung, Y.H., Fong, D.Y., Au, W.Y., Kwong, Y.L., Lie, A., Hou, J.L., Wen, Y.M., Nanj, A., Liang, R. Blood (2002) [Pubmed]
  9. Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements. Dostie, J., Richmond, T.A., Arnaout, R.A., Selzer, R.R., Lee, W.L., Honan, T.A., Rubio, E.D., Krumm, A., Lamb, J., Nusbaum, C., Green, R.D., Dekker, J. Genome Res. (2006) [Pubmed]
  10. Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina. Zoidl, G., Bruzzone, R., Weickert, S., Kremer, M., Zoidl, C., Mitropoulou, G., Srinivas, M., Spray, D.C., Dermietzel, R. J. Biol. Chem. (2004) [Pubmed]
  11. Diagnosis of human papillomavirus genital tract infection. Trofatter, K.F. Am. J. Med. (1997) [Pubmed]
  12. Multi-measurement method comparison of three commercial hepatitis B virus DNA quantification assays. Krajden, M., Minor, J., Cork, L., Comanor, L. J. Viral Hepat. (1998) [Pubmed]
  13. Factors associated with an increased risk of prevalent and incident grade III cervical intraepithelial neoplasia and invasive cervical cancer among women with Papanicolaou tests classified as grades I or II cervical intraepithelial neoplasia. Petry, K.U., Böhmer, G., Iftner, T., Davies, P., Brummer, O., Kühnle, H. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  14. In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue. Mishima, Y., Imahori, Y., Honda, C., Hiratsuka, J., Ueda, S., Ido, T. J. Neurooncol. (1997) [Pubmed]
  15. Performance of a Commercial Immunoglobulin M Antibody Capture Assay Using Analyte-Specific Reagents To Screen for Interfering Factors during a West Nile Virus Epidemic Season in Nebraska. Sambol, A.R., Hinrichs, S.H., Hogrefe, W.R., Schweitzer, B.K. Clin. Vaccine Immunol. (2007) [Pubmed]
  16. High-throughput cervical cancer screening using intracellular human papillomavirus E6 and E7 mRNA quantification by flow cytometry. Narimatsu, R., Patterson, B.K. Am. J. Clin. Pathol. (2005) [Pubmed]
  17. Comparison of the Murex Hybrid Capture CMV DNA (v2.0) assay and the pp65 CMV antigenemia test for the detection and quantitation of CMV in blood samples from immunocompromised patients. Schirm, J., Kooistra, A., van Son, W.J., van der Bij, W., Verschuuren, E., Sprenger, H.G., Limburg, P.C., The, T.H. J. Clin. Virol. (1999) [Pubmed]
  18. What constitutes a population for the plant parasitic nematode Globodera pallida in its native area (Peru)? Picard, D., Plantard, O. Int. J. Parasitol. (2006) [Pubmed]
  19. Analytic sensitivities of hybrid-capture, consensus and type-specific polymerase chain reactions for the detection of human papillomavirus type 16 DNA. Cavuslu, S., Mant, C., Starkey, W.G., Bible, J.M., Biswas, C., Kell, B., Rice, P., Best, J.M., Cason, J. J. Med. Virol. (1996) [Pubmed]
  20. DNA- versus RNA-based methods for human papillomavirus detection in cervical neoplasia. Lie, A.K., Risberg, B., Borge, B., Sandstad, B., Delabie, J., Rimala, R., Onsrud, M., Thoresen, S. Gynecol. Oncol. (2005) [Pubmed]
  21. Real-time RT-PCR for the detection of beta-adrenoceptor messenger RNAs in small human endomyocardial biopsies. Moniotte, S., Vaerman, J.L., Kockx, M.M., Larrouy, D., Langin, D., Noirhomme, P., Balligand, J.L. J. Mol. Cell. Cardiol. (2001) [Pubmed]
  22. Evaluation of the murex hybrid capture cytomegalovirus DNA assay versus plasma PCR and shell vial assay for diagnosis of human cytomegalovirus viremia in immunocompromised patients. Barrett-Muir, W.Y., Aitken, C., Templeton, K., Raftery, M., Kelsey, S.M., Breuer, J. J. Clin. Microbiol. (1998) [Pubmed]
  23. Moderate variation of the oncogenic potential among high-risk human papillomavirus types in gynecologic patients with cervical abnormalities. Szoke, K., Sápy, T., Krasznai, Z., Hernádi, Z., Szládek, G., Veress, G., Dillner, J., Gergely, L., Kónya, J. J. Med. Virol. (2003) [Pubmed]
  24. Evaluation of the Murex CMV DNA Hybrid Capture assay (version 2.0) for early diagnosis of cytomegalovirus infection in recipients of an allogeneic stem cell transplant. Hebart, H., Wuchter, P., Loeffler, J., Gscheidle, B., Hamprecht, K., Sinzger, C., Jahn, G., Dietz, K., Kanz, L., Einsele, H. Bone Marrow Transplant. (2001) [Pubmed]
  25. Synthesis of Boron Cluster Lipids: closo-Dodecaborate as an Alternative Hydrophilic Function of Boronated Liposomes for Neutron Capture Therapy. Lee, J.D., Ueno, M., Miyajima, Y., Nakamura, H. Org. Lett. (2007) [Pubmed]
  26. The efficacy of reprocessing unsatisfactory cervicovaginal ThinPrep specimens with and without glacial acetic acid: effect on Hybrid Capture II human papillomavirus testing and clinical follow-up. Agoff, S.N., Dean, T., Nixon, B.K., Ingalls-Severn, K., Rinker, L., Grieco, V.S. Am. J. Clin. Pathol. (2002) [Pubmed]
  27. Human papillomavirus and cervical neoplasia. Einstein, M.H., Goldberg, G.L. Cancer Invest. (2002) [Pubmed]
  28. Evaluation of adjunctive HPV testing by Hybrid Capture II in women with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy. Guyot, A., Karim, S., Kyi, M.S., Fox, J. BMC Infect. Dis. (2003) [Pubmed]
  29. Novel splice variants of cyclin E with altered substrate specificity. Porter, D.C., Keyomarsi, K. Nucleic Acids Res. (2000) [Pubmed]
  30. Soluble HLA-G circulates in maternal blood during pregnancy. Hunt, J.S., Jadhav, L., Chu, W., Geraghty, D.E., Ober, C. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  31. Modulation of IL-1beta, IL-6, TNF-alpha and PGE(2) by pharmacological agents in explants of membranes from failed total hip replacement. Lavigne, P., Shi, Q., Jolicoeur, F.C., Pelletier, J.P., Martel-Pelletier, J., Fernandes, J.C. Osteoarthr. Cartil. (2002) [Pubmed]
  32. IL-10 promoter nt -1082A/G polymorphism and human papillomavirus infection in cytologic abnormalities of the uterine cervix. Szöke, K., Szalmás, A., Szládek, G., Veress, G., Gergely, L., Tóth, F.D., Kónya, J. J. Interferon Cytokine Res. (2004) [Pubmed]
  33. HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica. Schiffman, M., Herrero, R., Hildesheim, A., Sherman, M.E., Bratti, M., Wacholder, S., Alfaro, M., Hutchinson, M., Morales, J., Greenberg, M.D., Lorincz, A.T. JAMA (2000) [Pubmed]
  34. Anal intraepithelial neoplasia in heterosexual and homosexual HIV-positive men with access to antiretroviral therapy. Wilkin, T.J., Palmer, S., Brudney, K.F., Chiasson, M.A., Wright, T.C. J. Infect. Dis. (2004) [Pubmed]
  35. Silicon-based biosensors for rapid detection of protein or nucleic acid targets. Jenison, R., La, H., Haeberli, A., Ostroff, R., Polisky, B. Clin. Chem. (2001) [Pubmed]
  36. Papanicolaou tests and molecular analyses using new fluid-based specimen collection technology in 3000 Japanese women. Masumoto, N., Fujii, T., Ishikawa, M., Mukai, M., Saito, M., Iwata, T., Fukuchi, T., Kubushiro, K., Tsukazaki, K., Nozawa, S. Br. J. Cancer (2003) [Pubmed]
  37. Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA. Caliendo, A.M., Yen-Lieberman, B., Baptista, J., Andersen, J., Crumpacker, C., Schuurman, R., Spector, S.A., Bremer, J., Lurain, N.S. J. Clin. Microbiol. (2003) [Pubmed]
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