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Gene Review

Chrnb1  -  cholinergic receptor, nicotinic, beta...

Mus musculus

Synonyms: AChR beta, Acetylcholine receptor subunit beta, Achr-2, Acrb
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Disease relevance of Chrnb1


High impact information on Chrnb1

  • From these data, we could estimate the location of the nu gene, not only genetically but also physically within a region that spans approximately 17 megabases (9 cM) between the Acrb and Mpo genes [2].
  • In contrast, LOH was not detected in 20 liver tumors from methylene chloride-treated mice at the Acrb locus, which is tightly linked to the p53 gene on chromosome 11 [3].
  • Mapping of markers in both the T16Ad14B and T16Ad19A hybrids localized the T16Ad translocation breakpoint between the proximal markers Atplb2 and Acrb and the more distal markers Scya2 and Mpo [4].


  1. Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Zhuang, S.M., Eklund, L.K., Cochran, C., Rao, G.N., Wiseman, R.W., Söderkvist, P. Cancer Res. (1996) [Pubmed]
  2. Mapping of the nu gene using congenic nude strains and in situ hybridization. Takahashi, Y., Shimizu, A., Sakai, T., Endo, Y., Osawa, N., Shisa, H., Honjo, T. J. Exp. Med. (1992) [Pubmed]
  3. Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice. Hegi, M.E., Söderkvist, P., Foley, J.F., Schoonhoven, R., Swenberg, J.A., Kari, F., Maronpot, R., Anderson, M.W., Wiseman, R.W. Carcinogenesis (1993) [Pubmed]
  4. Derivation and characterization of a somatic cell hybrid containing the portion of mouse chromosome 11 (MMU11) homologous to human chromosome 17q. Morris-Rosendahl, D.J., Schriever-Schwemmer, G., Robinson, T.J. J. Hered. (1996) [Pubmed]
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