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Gene Review

Klf4  -  Kruppel-like factor 4 (gut)

Rattus norvegicus

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Disease relevance of Klf4

  • Furthermore, a GKLF overexpressing adenovirus inhibited whereas GKLF morpholino antisense oligos increased expression of endogenous SMC marker genes [1].

High impact information on Klf4


Biological context of Klf4

  • The aims of the present studies were to: 1) determine the role of the SM alpha-actin TCE in vivo through mutagenesis studies in transgenic mice and 2) further characterize the possible role and mechanisms by which the TCE-binding factor GKLF/KLF4 induces repression of SMC marker genes in various SMC model systems in vitro [1].

Other interactions of Klf4

  • A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression [1].

Analytical, diagnostic and therapeutic context of Klf4


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