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NOSTRIN  -  nitric oxide synthase trafficking

Homo sapiens

Synonyms: BM247 homolog, MGC20702, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, Nostrin, ...
 
 
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Disease relevance of NOSTRIN

  • OBJECTIVE: To investigate the expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) in the placenta of women with pre-eclampsia (PE) and discuss its role in the pathogenesis of PE [1].
 

High impact information on NOSTRIN

 

Biological context of NOSTRIN

 

Anatomical context of NOSTRIN

  • If, however, the actin cytoskeleton is depolymerized by cytochalasin D, NOSTRIN and eNOS are associated with extended structures in the cell periphery, possibly being unable to leave the plasma membrane [4].
 

Associations of NOSTRIN with chemical compounds

 

Other interactions of NOSTRIN

  • NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS [4].
  • Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN [3].
 

Analytical, diagnostic and therapeutic context of NOSTRIN

References

  1. Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with pre-eclampsia. Xiang, W., Chen, H., Xu, X., Zhang, M., Jiang, R. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (2005) [Pubmed]
  2. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Zimmermann, K., Opitz, N., Dedio, J., Renne, C., Muller-Esterl, W., Oess, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Schilling, K., Opitz, N., Wiesenthal, A., Oess, S., Tikkanen, R., Müller-Esterl, W., Icking, A. Mol. Biol. Cell (2006) [Pubmed]
  4. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. Icking, A., Matt, S., Opitz, N., Wiesenthal, A., Müller-Esterl, W., Schilling, K. J. Cell. Sci. (2005) [Pubmed]
  5. FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. Icking, A., Schilling, K., Wiesenthal, A., Opitz, N., Müller-Esterl, W. FEBS Lett. (2006) [Pubmed]
 
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