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Gene Review

TGM7  -  transglutaminase 7

Homo sapiens

Synonyms: Protein-glutamine gamma-glutamyltransferase Z, TG(Z), TGMZ, TGZ, TGase Z, ...
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High impact information on TGM7

  • However, only MCF-7, MDA-MB-231, and ZR-75-1 cells, which expressed a high level of bcl-2 protein, underwent apoptosis when exposed to the combination of TGZ and either ATRA or 9-cis-RA [1].
  • The cell lines (MCF-7, T-47D, ZR-75-1), which expressed both BRCA1 and p27, were extremely sensitive to the inhibitory effect of the combination of TGZ and either ATRA or 9-cis-RA (ED90, 2-5 x 10(-11) M) [1].
  • The levels of BCSG-1 significantly correlated with an associated molecule, transglutaminase-3 (r = 0.307, P < 0.05), and weakly with transglutaminase-7 (r = 0.183) [2].
  • Subjects were treated with a thiazolidinedione (troglitazone, TGZ) or a biguanide (metformin, MET) in addition to glyburide for 3 to 4 months [3].
  • From these results we conclude that the higher potency of TGZ to increase capillary density and reduce the lipid content of muscle may contribute to its greater ability to improve glucose disposal in skeletal muscle of type 2 diabetic individuals [3].


  1. Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells. Elstner, E., Williamson, E.A., Zang, C., Fritz, J., Heber, D., Fenner, M., Possinger, K., Koeffler, H.P. Breast Cancer Res. Treat. (2002) [Pubmed]
  2. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Martin, T.A., Gomez, K., Watkins, G., Douglas-Jones, A., Mansel, R.E., Jiang, W.G. Oncol. Rep. (2006) [Pubmed]
  3. Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal. Mathieu-Costello, O., Kong, A., Ciaraldi, T.P., Cui, L., Ju, Y., Chu, N., Kim, D., Mudaliar, S., Henry, R.R. Metab. Clin. Exp. (2003) [Pubmed]
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