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Chemical Compound Review

Resulin     5-[[4-[(6-hydroxy-2,5,7,8- tetramethyl...

Synonyms: Rezulin, Romozin, Noscal, Prelay, Romglizone, ...
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Disease relevance of Rezulin


Psychiatry related information on Rezulin


High impact information on Rezulin


Chemical compound and disease context of Rezulin


Biological context of Rezulin


Anatomical context of Rezulin

  • These results suggest that the primary action of troglitazone may be to increase the number of small adipocytes in white adipose tissues, presumably via PPARgamma [20].
  • In fact, the percentage of apoptotic nuclei was approximately 2.5-fold higher in the troglitazone-treated retroperitoneal white adipose tissue than control [20].
  • We evaluated the ability of troglitazone, alone or in combination with retinoids, to prevent the induction of preneoplastic lesions by 7,12-dimethylbenz[a]anthracene (DMBA) in a mouse mammary gland organ culture model [10].
  • INTERVENTION: 6 months of therapy with troglitazone, 200 to 600 mg/d. MEASUREMENTS: Levels of hemoglobin A1c triglycerides, free fatty acids, and insulin; respiratory quotient; percentage of body fat; liver volume; and regional fat mass [21].
  • Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets [22].

Associations of Rezulin with other chemical compounds


Gene context of Rezulin


Analytical, diagnostic and therapeutic context of Rezulin


  1. Effect of troglitazone in type 2 diabetes mellitus. Rusk, M.H. N. Engl. J. Med. (1998) [Pubmed]
  2. Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group. Schwartz, S., Raskin, P., Fonseca, V., Graveline, J.F. N. Engl. J. Med. (1998) [Pubmed]
  3. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. Nolan, J.J., Ludvik, B., Beerdsen, P., Joyce, M., Olefsky, J. N. Engl. J. Med. (1994) [Pubmed]
  4. Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Sarraf, P., Mueller, E., Jones, D., King, F.J., DeAngelo, D.J., Partridge, J.B., Holden, S.A., Chen, L.B., Singer, S., Fletcher, C., Spiegelman, B.M. Nat. Med. (1998) [Pubmed]
  5. Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control. Osende, J.I., Badimon, J.J., Fuster, V., Herson, P., Rabito, P., Vidhun, R., Zaman, A., Rodriguez, O.J., Lev, E.I., Rauch, U., Heflt, G., Fallon, J.T., Crandall, J.P. J. Am. Coll. Cardiol. (2001) [Pubmed]
  6. Effects of troglitazone: a new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy. Iwamoto, Y., Kosaka, K., Kuzuya, T., Akanuma, Y., Shigeta, Y., Kaneko, T. Diabetes Care (1996) [Pubmed]
  7. Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients. Shimizu, H., Tsuchiya, T., Sato, N., Shimomura, Y., Kobayashi, I., Mori, M. Diabetes Care (1998) [Pubmed]
  8. Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. d'Abramo, C., Ricciarelli, R., Pronzato, M.A., Davies, P. J. Neurochem. (2006) [Pubmed]
  9. Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells. Yamamoto, Y., Yamazaki, H., Ikeda, T., Watanabe, T., Iwabuchi, H., Nakajima, M., Yokoi, T. Drug Metab. Dispos. (2002) [Pubmed]
  10. A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions. Mehta, R.G., Williamson, E., Patel, M.K., Koeffler, H.P. J. Natl. Cancer Inst. (2000) [Pubmed]
  11. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. Kawahito, Y., Kondo, M., Tsubouchi, Y., Hashiramoto, A., Bishop-Bailey, D., Inoue, K., Kohno, M., Yamada, R., Hla, T., Sano, H. J. Clin. Invest. (2000) [Pubmed]
  12. Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer. Hisatake, J.I., Ikezoe, T., Carey, M., Holden, S., Tomoyasu, S., Koeffler, H.P. Cancer Res. (2000) [Pubmed]
  13. Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice. Lu, J., Imamura, K., Nomura, S., Mafune, K., Nakajima, A., Kadowaki, T., Kubota, N., Terauchi, Y., Ishii, G., Ochiai, A., Esumi, H., Kaminishi, M. Cancer Res. (2005) [Pubmed]
  14. Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats. Qiang, X., Satoh, J., Sagara, M., Fukuzawa, M., Masuda, T., Sakata, Y., Muto, G., Muto, Y., Takahashi, K., Toyota, T. Diabetologia (1998) [Pubmed]
  15. Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Bressler, R., Johnson, D.G. Arch. Intern. Med. (1997) [Pubmed]
  16. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia. Law, R.E., Meehan, W.P., Xi, X.P., Graf, K., Wuthrich, D.A., Coats, W., Faxon, D., Hsueh, W.A. J. Clin. Invest. (1996) [Pubmed]
  17. Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity. Shimabukuro, M., Koyama, K., Lee, Y., Unger, R.H. J. Clin. Invest. (1997) [Pubmed]
  18. Troglitazone action is independent of adipose tissue. Burant, C.F., Sreenan, S., Hirano, K., Tai, T.A., Lohmiller, J., Lukens, J., Davidson, N.O., Ross, S., Graves, R.A. J. Clin. Invest. (1997) [Pubmed]
  19. Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Shimizu, K., Kobayashi, M., Tahara, J., Shiratori, K. Gastroenterology (2005) [Pubmed]
  20. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., Kadowaki, T. J. Clin. Invest. (1998) [Pubmed]
  21. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Arioglu, E., Duncan-Morin, J., Sebring, N., Rother, K.I., Gottlieb, N., Lieberman, J., Herion, D., Kleiner, D.E., Reynolds, J., Premkumar, A., Sumner, A.E., Hoofnagle, J., Reitman, M.L., Taylor, S.I. Ann. Intern. Med. (2000) [Pubmed]
  22. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Kakuma, T., Lee, Y., Higa, M., Wang, Z., Pan, W., Shimomura, I., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. Ribon, V., Johnson, J.H., Camp, H.S., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  24. Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Wang, C., Fu, M., D'Amico, M., Albanese, C., Zhou, J.N., Brownlee, M., Lisanti, M.P., Chatterjee, V.K., Lazar, M.A., Pestell, R.G. Mol. Cell. Biol. (2001) [Pubmed]
  25. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Marx, N., Schönbeck, U., Lazar, M.A., Libby, P., Plutzky, J. Circ. Res. (1998) [Pubmed]
  26. 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. Piva, R., Gianferretti, P., Ciucci, A., Taulli, R., Belardo, G., Santoro, M.G. Blood (2005) [Pubmed]
  27. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Wang, C., Pattabiraman, N., Zhou, J.N., Fu, M., Sakamaki, T., Albanese, C., Li, Z., Wu, K., Hulit, J., Neumeister, P., Novikoff, P.M., Brownlee, M., Scherer, P.E., Jones, J.G., Whitney, K.D., Donehower, L.A., Harris, E.L., Rohan, T., Johns, D.C., Pestell, R.G. Mol. Cell. Biol. (2003) [Pubmed]
  28. Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. Koga, H., Sakisaka, S., Harada, M., Takagi, T., Hanada, S., Taniguchi, E., Kawaguchi, T., Sasatomi, K., Kimura, R., Hashimoto, O., Ueno, T., Yano, H., Kojiro, M., Sata, M. Hepatology (2001) [Pubmed]
  29. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Han, C., Demetris, A.J., Michalopoulos, G.K., Zhan, Q., Shelhamer, J.H., Wu, T. Hepatology (2003) [Pubmed]
  30. Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. Baek, S.J., Wilson, L.C., Hsi, L.C., Eling, T.E. J. Biol. Chem. (2003) [Pubmed]
  31. Troglitazone-induced hepatic failure leading to liver transplantation. A case report. Neuschwander-Tetri, B.A., Isley, W.L., Oki, J.C., Ramrakhiani, S., Quiason, S.G., Phillips, N.J., Brunt, E.M. Ann. Intern. Med. (1998) [Pubmed]
  32. Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human. Pancreatic carcinoma cells. Motomura, W., Okumura, T., Takahashi, N., Obara, T., Kohgo, Y. Cancer Res. (2000) [Pubmed]
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