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Gene Review

Myt1l  -  myelin transcription factor 1-like

Rattus norvegicus

Synonyms: MyT1-L, MyT1L, Myelin transcription factor 1-like protein, NZF-1, Neural zinc finger factor 1, ...
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High impact information on Myt1l

  • Unlike MyT1 and NZF-1, NZF-3 does not contain an acidic domain at the amino terminus or a serine/threonine-rich region between the two finger clusters [1].
  • The cDNA sequence predicts a protein of 1,032 amino acids which contains two clusters of zinc fingers similar to MyT1 and NZF-1 [1].
  • These results suggest that NZF-1 may exert regulatory roles in the developing and mature nervous system and in the pituitary gland [2].
  • In heterologous cells, NZF-1 activates transcription from promoters containing specific binding sequences and can synergize with other factors, such as Pit-1, to regulate gene expression [2].
  • This gene is expressed in a restricted fashion exhibiting distinct temporal and spatial patterns in the developing nervous system, primarily brain, spinal cord, sensory ganglia, retina, and nasal epithelia, as well as in the pituitary, and is referred to as neural zinc finger factor 1 (NZF-1) [2].

Biological context of Myt1l


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