Disease relevance of Capn9

• Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease [1].
• Moreover, the myocardial expression of calpain 9 protein was inversely linked to left ventricular mass (r= -0.93, p<0.01), and renal expression of calpain 9 protein correlated inversely with albuminuria (r= -0.82, p<0.05) [1].

High impact information on Capn9

• On the protein level, calpain 9 but not calpastatin was regulated in the hypertensive target organs heart and kidney [1].
• Northern blot analysis revealed that the mRNA for nCL-4 is expressed predominantly in stomach and small intestine but not in uterus, suggesting specialized functions of nCL-4 in the digestive tract [2].
• In addition, the gene coding for nCL-4 was localized on human chromosome 1 [2].
• The deduced amino acid sequence revealed that nCL-4 is highly conserved among mammals. nCL-4 can be aligned without significant deletions or insertions, and, thus, like other calpains, can be divided into four domains (I-IV) [2].

References