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Gene Review

Cast  -  calpastatin

Rattus norvegicus

Synonyms: Calpain inhibitor, Calpastatin
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  1. A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Posmantur, R., Kampfl, A., Siman, R., Liu, J., Zhao, X., Clifton, G.L., Hayes, R.L. Neuroscience (1997) [Pubmed]
  2. Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat. Weber, H., Jonas, L., Hühns, S., Schuff-Werner, P. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  3. Calpain activity and expression are increased in splenic inflammatory cells associated with experimental allergic encephalomyelitis. Shields, D.C., Schaecher, K.E., Goust, J.M., Banik, N.L. J. Neuroimmunol. (1999) [Pubmed]
  4. Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. Wei, W., Fareed, M.U., Evenson, A., Menconi, M.J., Yang, H., Petkova, V., Hasselgren, P.O. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  5. Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia. Tamada, Y., Nakajima, E., Nakajima, T., Shearer, T.R., Azuma, M. Brain Res. (2005) [Pubmed]
  6. A Ca(2+) switch aligns the active site of calpain. Moldoveanu, T., Hosfield, C.M., Lim, D., Elce, J.S., Jia, Z., Davies, P.L. Cell (2002) [Pubmed]
  7. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. Kohli, V., Madden, J.F., Bentley, R.C., Clavien, P.A. Gastroenterology (1999) [Pubmed]
  8. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Miyoshi, H., Umeshita, K., Sakon, M., Imajoh-Ohmi, S., Fujitani, K., Gotoh, M., Oiki, E., Kambayashi, J., Monden, M. Gastroenterology (1996) [Pubmed]
  9. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Saatman, K.E., Murai, H., Bartus, R.T., Smith, D.H., Hayward, N.J., Perri, B.R., McIntosh, T.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity. Limaye, P.B., Bhave, V.S., Palkar, P.S., Apte, U.M., Sawant, S.P., Yu, S., Latendresse, J.R., Reddy, J.K., Mehendale, H.M. Hepatology (2006) [Pubmed]
  11. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Brorson, J.R., Marcuccilli, C.J., Miller, R.J. Stroke (1995) [Pubmed]
  12. The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia. Kunz, S., Niederberger, E., Ehnert, C., Coste, O., Pfenninger, A., Kruip, J., Wendrich, T.M., Schmidtko, A., Tegeder, I., Geisslinger, G. Pain (2004) [Pubmed]
  13. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Edelstein, C.L., Yaqoob, M.M., Alkhunaizi, A.M., Gengaro, P.E., Nemenoff, R.A., Wang, K.K., Schrier, R.W. Kidney Int. (1996) [Pubmed]
  14. Calpain, calpastatin activities and ratios during myocardial ischemia-reperfusion. Enns, D., Karmazyn, M., Mair, J., Lercher, A., Kountchev, J., Belcastro, A. Mol. Cell. Biochem. (2002) [Pubmed]
  15. Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal. Azuma, M., David, L.L., Shearer, T.R. Curr. Eye Res. (1991) [Pubmed]
  16. Higher calpastatin levels correlate with resistance to calpain-mediated proteolysis and neuronal apoptosis in juvenile rats after spinal cord injury. Wingrave, J.M., Sribnick, E.A., Wilford, G.G., Matzelle, D.D., Mou, J.A., Ray, S.K., Hogan, E.L., Banik, N.L. J. Neurotrauma (2004) [Pubmed]
  17. Transcriptional and translational regulation of calpain in the rat heart after myocardial infarction--effects of AT(1) and AT(2) receptor antagonists and ACE inhibitor. Sandmann, S., Yu, M., Unger, T. Br. J. Pharmacol. (2001) [Pubmed]
  18. Rat brain contains multiple mRNAs for calpastatin. De Tullio, R., Sparatore, B., Salamino, F., Melloni, E., Pontremoli, S. FEBS Lett. (1998) [Pubmed]
  19. Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells. Ray, S.K., Wilford, G.G., Crosby, C.V., Hogan, E.L., Banik, N.L. Brain Res. (1999) [Pubmed]
  20. Nerve growth factor-induced decrease in the calpain activity of PC12 cells. Oshima, M., Koizumi, S., Fujita, K., Guroff, G. J. Biol. Chem. (1989) [Pubmed]
  21. Calpain expression varies among different rat and bovine central nervous system regions. Shields, D.C., Ray, S.K., Gantt-Wilford, G., Banik, N.L. J. Neurosci. Res. (1998) [Pubmed]
  22. Overexpression of calpastatin inhibits L8 myoblast fusion. Barnoy, S., Maki, M., Kosower, N.S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  23. Calcium Influx through L-type Channels Generates Protein Kinase M to Induce Burst Firing of Dopamine Cells in the Rat Ventral Tegmental Area. Liu, Y., Dore, J., Chen, X. J. Biol. Chem. (2007) [Pubmed]
  24. Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain. Wu, H.Y., Tomizawa, K., Matsushita, M., Lu, Y.F., Li, S.T., Matsui, H. Neurosci. Res. (2003) [Pubmed]
  25. Modulation of calcium-dependent neutral protease activity by fatty acids and lysophospholipids. Zalewska, T., Strosznajder, J., Kawashima, S. Neurochemical pathology. (1988) [Pubmed]
  26. Gonadal steroid regulation of renal injury in renal wrap hypertension. Ji, H., Menini, S., Mok, K., Zheng, W., Pesce, C., Kim, J., Mulroney, S., Sandberg, K. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  27. Hydrophobic association of calpains with subcellular organelles. Compartmentalization of calpains and the endogenous inhibitor calpastatin in tissues. Gopalakrishna, R., Barsky, S.H. J. Biol. Chem. (1986) [Pubmed]
  28. Characterization and regulation of lens-specific calpain Lp82. Fukiage, C., Nakajima, E., Ma, H., Azuma, M., Shearer, T.R. J. Biol. Chem. (2002) [Pubmed]
  29. Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor. Nakamura, Y., Fukiage, C., Ma, H., Shih, M., Azuma, M., Shearer, T.R. Exp. Eye Res. (1999) [Pubmed]
  30. Variants of the receptor/channel clustering molecule gephyrin in brain: distinct distribution patterns, developmental profiles, and proteolytic cleavage by calpain. Kawasaki, B.T., Hoffman, K.B., Yamamoto, R.S., Bahr, B.A. J. Neurosci. Res. (1997) [Pubmed]
  31. Intrinsic myofilament alterations underlying the decreased contractility of stunned myocardium. A consequence of Ca2+-dependent proteolysis? Gao, W.D., Liu, Y., Mellgren, R., Marban, E. Circ. Res. (1996) [Pubmed]
  32. Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. Ray, S.K., Fidan, M., Nowak, M.W., Wilford, G.G., Hogan, E.L., Banik, N.L. Brain Res. (2000) [Pubmed]
  33. Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion. Shi, Y., Melnikov, V.Y., Schrier, R.W., Edelstein, C.L. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  34. Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease. Markmann, A., Schäfer, S., Linz, W., Löhn, M., Busch, A.E., Wohlfart, P. Cell. Physiol. Biochem. (2005) [Pubmed]
  35. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. Rajala, R.V., Kakkar, R., Kanthan, R., Radhi, J.M., Wang, X., Wang, R., Datla, R.S., Sharma, R.K. J. Cell. Biochem. (2002) [Pubmed]
  36. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. Kusakawa, G., Saito, T., Onuki, R., Ishiguro, K., Kishimoto, T., Hisanaga, S. J. Biol. Chem. (2000) [Pubmed]
  37. Upregulation of calpain activity and expression in experimental allergic encephalomyelitis: a putative role for calpain in demyelination. Shields, D.C., Banik, N.L. Brain Res. (1998) [Pubmed]
  38. Association of calpain (Ca(2+)-dependent thiol protease) with its endogenous inhibitor calpastatin in myoblasts. Barnoy, S., Zipser, Y., Glaser, T., Grimberg, Y., Kosower, N.S. J. Cell. Biochem. (1999) [Pubmed]
  39. Calpain inhibitor-1 reduces infarct size and DNA fragmentation of myocardium in ischemic/reperfused rat heart. Iwamoto, H., Miura, T., Okamura, T., Shirakawa, K., Iwatate, M., Kawamura, S., Tatsuno, H., Ikeda, Y., Matsuzaki, M. J. Cardiovasc. Pharmacol. (1999) [Pubmed]
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