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Gene Review

Heph  -  hephaestin

Rattus norvegicus

Synonyms: Hephaestin
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Disease relevance of Heph

  • We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response [1].

High impact information on Heph

  • Negative effects of Zn supplementation on Fe absorption were associated with increased small intestine Fe retention, decreased hephaestin, and increased FPN expression [2].
  • At mid- (PN10) and late (PN20) infancy, tissue Fe distribution, Fe absorption, intestine DMT1, ferroportin-1 (FPN) and hephaestin expression, and localization and liver hepcidin expression were measured [2].
  • Hp protein in enterocytes of CuD rats of both sexes was only 35% of that in CuA rats [3].
  • Genes encoding the apical iron transport-related proteins [divalent metal transporter 1 (DMT1) and duodenal cytochrome b] were strongly induced at all ages studied, whereas increases in mRNA encoding the basolateral proteins iron-regulated gene 1 and hephaestin were observed only by real-time PCR [4].
  • The mechanism for reduced Fe absorption in Cu deficiency is unknown, but may involve the intestinal Cu-dependent ferroxidase, Hephaestin (Hp) [3].

Anatomical context of Heph


  1. Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Anderson, G.J., Frazer, D.M., Wilkins, S.J., Becker, E.M., Millard, K.N., Murphy, T.L., McKie, A.T., Vulpe, C.D. Biochem. Soc. Trans. (2002) [Pubmed]
  2. Zinc Supplementation Reduces Iron Absorption through Age-Dependent Changes in Small Intestine Iron Transporter Expression in Suckling Rat Pups. Kelleher, S.L., Lönnerdal, B. J. Nutr. (2006) [Pubmed]
  3. Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. Reeves, P.G., Demars, L.C., Johnson, W.T., Lukaski, H.C. J. Nutr. (2005) [Pubmed]
  4. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Collins, J.F., Franck, C.A., Kowdley, K.V., Ghishan, F.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  5. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Frazer, D.M., Vulpe, C.D., McKie, A.T., Wilkins, S.J., Trinder, D., Cleghorn, G.J., Anderson, G.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
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