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Gene Review

EF0485  -  aggregation substance

Enterococcus faecalis V583

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Disease relevance of EF0485


High impact information on EF0485


Biological context of EF0485


Analytical, diagnostic and therapeutic context of EF0485


  1. An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid. Waters, C.M., Hirt, H., McCormick, J.K., Schlievert, P.M., Wells, C.L., Dunny, G.M. Mol. Microbiol. (2004) [Pubmed]
  2. The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes. Waters, C.M., Wells, C.L., Dunny, G.M. Infect. Immun. (2003) [Pubmed]
  3. In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10. Hirt, H., Schlievert, P.M., Dunny, G.M. Infect. Immun. (2002) [Pubmed]
  4. Aggregation substance promotes adherence, phagocytosis, and intracellular survival of Enterococcus faecalis within human macrophages and suppresses respiratory burst. Süssmuth, S.D., Muscholl-Silberhorn, A., Wirth, R., Susa, M., Marre, R., Rozdzinski, E. Infect. Immun. (2000) [Pubmed]
  5. Aggregation substance increases adherence and internalization, but not translocation, of Enterococcus faecalis through different intestinal epithelial cells in vitro. Sartingen, S., Rozdzinski, E., Muscholl-Silberhorn, A., Marre, R. Infect. Immun. (2000) [Pubmed]
  6. Inducible expression of Enterococcus faecalis aggregation substance surface protein facilitates bacterial internalization by cultured enterocytes. Wells, C.L., Moore, E.A., Hoag, J.A., Hirt, H., Dunny, G.M., Erlandsen, S.L. Infect. Immun. (2000) [Pubmed]
  7. Plasmid content of Streptococcus faecalis strain 39-5 and identification of a pheromone (cPD1)-induced surface antigen. Yagi, Y., Kessler, R.E., Shaw, J.H., Lopatin, D.E., An, F., Clewell, D.B. J. Gen. Microbiol. (1983) [Pubmed]
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