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Gene Review

GYLTL1B  -  glycosyltransferase-like 1B

Homo sapiens

Synonyms: FLJ35207, Glycosyltransferase-like 1B, Glycosyltransferase-like protein LARGE2, LARGE2, PP5656
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Disease relevance of GYLTL1B


High impact information on GYLTL1B

  • The unambiguous assignments deduced from the 15N labeling studies have been verified from an independent labeling strategy where individual guanines in the internal loop have been replaced, one at a time, by inosines and assignments were made on the basis of the large 2 ppm downfield shift of the guanine imino protons on inosine substitution [5].
  • RT-PCR, dot-blot, and northern analysis indicated that LARGE2 has a more restricted tissue-expression profile than LARGE1 [6].
  • Overexpression of LARGE2 in mouse C2C12 myoblasts results in increased glycosylation of alpha-DG accompanied by an increase in laminin binding [6].
  • This is the case of a large 2 x 1.5 cm adrenal tumor demonstrated on CT scan that was proven biochemically and surgically to be an aldosteronoma and that did not concentrate 6-beta(131I)-iodo-methyl-19-norcholesterol (NP-59) [7].
  • To evaluate whether these in vitro data can be extrapolated in vivo, a large 2 phase trial has been initiated in the Netherlands in which the combination of CsA with chloroquine is evaluated in patients with RA [8].

Anatomical context of GYLTL1B

  • Whereas scanning electron microscopy is more commonly employed to record surface topography, it can be used to examine freeze-fracture planes within the myocardium and, using heavy-metal staining and back-scattered electron imaging, to examine large 2-mu-thick resin-embedded sections through the heart [9].

Analytical, diagnostic and therapeutic context of GYLTL1B


  1. Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy. Brockington, M., Torelli, S., Prandini, P., Boito, C., Dolatshad, N.F., Longman, C., Brown, S.C., Muntoni, F. Hum. Mol. Genet. (2005) [Pubmed]
  2. Protection against rotavirus disease after natural rotavirus infection. US Rotavirus Vaccine Efficacy Group. Ward, R.L., Bernstein, D.I. J. Infect. Dis. (1994) [Pubmed]
  3. Use of intraoperative computed tomography during repair of orbitozygomatic fractures. Stanley, R.B. Archives of facial plastic surgery : official publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies. (1999) [Pubmed]
  4. Middle colic artery thrombosis as a result of retained intraperitoneal gallstone after laparoscopic cholecystectomy. AlSamkari, R., Hassan, M. Surgical laparoscopy, endoscopy & percutaneous techniques. (2004) [Pubmed]
  5. Specific labeling approaches to guanine and adenine imino and amino proton assignments in the AMP-RNA aptamer complex. Jiang, F., Patel, D.J., Zhang, X., Zhao, H., Jones, R.A. J. Biomol. NMR (1997) [Pubmed]
  6. Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. Grewal, P.K., McLaughlan, J.M., Moore, C.J., Browning, C.A., Hewitt, J.E. Glycobiology (2005) [Pubmed]
  7. Case report: failure of adrenal scintigraphy to exhibit 131I cholesterol uptake in a CT-demonstrated, surgically proven aldosteronoma. Salam, Z., Lubbos, H., Martinez, C., Mozley, P.D., Miller, J.L., Rose, L.I. Am. J. Med. Sci. (1996) [Pubmed]
  8. Chloroquine combined with cyclosporine in rheumatoid arthritis: more than the addition of 2 drugs alone. Dijkmans, B.A., van den Borne, B.E., Landewe, R.B., Miltenburg, A.M., Verweij, C.L., Breedveld, F.C. The Journal of rheumatology. Supplement. (1996) [Pubmed]
  9. Interrelationships of ultrastructure and function in the microvasculature of normal and ischaemic myocardium. Gavin, J.B., Maxwell, L., Sage, M.D. Journal of electron microscopy technique. (1991) [Pubmed]
  10. Dilated cardiomyopathy: computer-assisted analysis of endomyocardial biopsy protein patterns by two-dimensional gel electrophoresis. Knecht, M., Regitz-Zagrosek, V., Pleissner, K.P., Emig, S., Jungblut, P., Hildebrandt, A., Fleck, E. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1994) [Pubmed]
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