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MeSH Review

Colon, Transverse

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Disease relevance of Colon, Transverse


High impact information on Colon, Transverse

  • Transit of the luminal contents was measured by following the movement of 99mTC-diethylenetriaminepentaacetic acid instilled as a bolus in the splenic flexure [6].
  • Movement of the luminal contents was measured by following the movement of technetium 99m-ethylenetriamine-pentaacetic acid that was instilled as a bolus in the splenic flexure [7].
  • Mucosal atrophy and focal dysplasia were present more frequently in specimens taken from the rectum (but not the splenic flexure) of dimethylhydrazine-treated animals than of control animals, but there was no correlation between the histochemical markers and either atrophy or dysplasia [8].
  • The effects of neurotensin on colonic motility were investigated in 6 healthy volunteers (rectosigmoid area) and 7 patients (ascending colon and at the splenic flexure) [9].
  • 4. Spinal anaesthesia produced by intrathecal lidocaine increased the motility of the transverse colon to a level which masked the gastrocolic reflex [10].

Chemical compound and disease context of Colon, Transverse

  • In order to achieve gastro-intestinal continuity and to avoid the torrential fluid loss associated with high fistula, an anastomosis between the stomach and the transverse colon was formed [11].

Biological context of Colon, Transverse


Anatomical context of Colon, Transverse


Associations of Colon, Transverse with chemical compounds

  • Normal and DMH-treated male rats aged 18-20 weeks underwent surgical transection and anastomosis of the transverse colon [19].
  • He subsequently developed toxic dilatation of the transverse colon while on salicylazosulfapyridine and one week after discontinuation of prednisone [20].
  • 6. Castor oil strongly increased the occurrence of manometrically recorded propulsive giant contractions (500 to 1000% over control values) of transverse and distal colon, this effect being significantly prevented (80 to 100%) by SR 48968 and loperamide and partially by SR 140333 (35% distal colon, 70% transverse colon) [21].
  • SR 48692 (10 nM - 10 microM) antagonized the NT response competitively in the distal colon (pA2 6.55, slope 0.79) and non-competitively in the transverse colon (pA2 8.0, slope 0.51) [22].
  • In conclusion, the use of cisapride may improve visualization of the transverse colon, but it did not result in significant improvement in the overall preparation score [23].

Gene context of Colon, Transverse


Analytical, diagnostic and therapeutic context of Colon, Transverse

  • The effects of morphine (0.1 mg/kg) and 5-HTP (2 mg/kg) on colonic motility were investigated in dogs fasted for 15-22 h and fitted with two strain gauge transducers on the transverse colon at 8 and 12 cm from the ileo-colonic junction [28].


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  2. Retrograde spread of 5-aminosalicylic acid enemas in patients with active ulcerative colitis. Campieri, M., Lanfranchi, G.A., Brignola, C., Bazzocchi, G., Gionchetti, P., Minguzzi, M.R., Cappello, I.P., Corbelli, C., Boschi, S. Dis. Colon Rectum (1986) [Pubmed]
  3. Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn's disease. Sorrentino, D., Avellini, C., Beltrami, C.A., Pasqual, E., Zearo, E. International journal of colorectal disease. (2006) [Pubmed]
  4. Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis. Chetty, R., Salahshor, S., Bapat, B., Berk, T., Croitoru, M., Gallinger, S. J. Clin. Pathol. (2005) [Pubmed]
  5. Mucinous carcinoma of the colon in a 16-year-old Turkish boy with Bloom syndrome: cytogenetic, histopathologic, TP53 gene and protein expression studies. Balci, S., Aktas, D. Cancer Genet. Cytogenet. (1999) [Pubmed]
  6. Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. Bazzocchi, G., Ellis, J., Villanueva-Meyer, J., Reddy, S.N., Mena, I., Snape, W.J. Gastroenterology (1991) [Pubmed]
  7. Association between postprandial changes in colonic intraluminal pressure and transit. Moreno-Osset, E., Bazzocchi, G., Lo, S., Trombley, B., Ristow, E., Reddy, S.N., Villanueva-Meyer, J., Fain, J.W., Jing, J., Mena, I. Gastroenterology (1989) [Pubmed]
  8. Serial observations of colonic carcinogenesis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Shioda, Y., Brown, W.R., Ahnen, D.J. Gastroenterology (1987) [Pubmed]
  9. Neurotensin increases colonic motility. Thor, K., Rosell, S. Gastroenterology (1986) [Pubmed]
  10. Spinal cord influences on the colonic myoelectrical activity of fed and fasted rats. Du, C., Ferré, J.P., Ruckebusch, Y. J. Physiol. (Lond.) (1987) [Pubmed]
  11. Gastro-colonic anastomosis--a viable option in extensive small bowel infarction. Thomas, A.D., Rocker, M.D., Morris-Stiff, G., Lewis, M.H. Annals of the Royal College of Surgeons of England. (2006) [Pubmed]
  12. Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet constant-release drug delivery system. Marvola, J., Kanerva, H., Slot, L., Lipponen, M., Kekki, T., Hietanen, H., Mykkänen, S., Ariniemi, K., Lindevall, K., Marvola, M. International journal of pharmaceutics. (2004) [Pubmed]
  13. Strangulated diaphragmatic hernia in a patient with osteogenesis imperfecta. Spence, P.A., Cohen, Z., Salerno, T.A. Canadian Medical Association journal. (1984) [Pubmed]
  14. Effects of dopamine and bromocriptine on colonic motility in dog. Bueno, L., Fargeas, M.J., Fioramonti, J., Honde, C. Br. J. Pharmacol. (1984) [Pubmed]
  15. Delayed presentation of intrapericardial diaphragmatic hernia, an unusual cause of colon obstruction. Beless, D.J., Organ, B.C. Annals of emergency medicine. (1991) [Pubmed]
  16. Neuropeptides in idiopathic chronic constipation (slow transit constipation). Sjölund, K., Fasth, S., Ekman, R., Hultén, L., Jiborn, H., Nordgren, S., Sundler, F. Neurogastroenterol. Motil. (1997) [Pubmed]
  17. Sulphation of the heterocyclic amine 1,2,3,4-tetrahydroisoquinoline in the human liver and intestinal mucosa: interindividual variability. Pacifici, G.M., D'alessandro, C., Gucci, A., Giuliani, L. Arch. Toxicol. (1997) [Pubmed]
  18. Site-dependent production of transforming growth factor beta1 in colonic mucosa: its possible role in tumorigenesis of the colon. Kushiyama, Y., Fukuda, R., Suetsugu, H., Kazumori, H., Ishihara, S., Adachi, K., Kinoshita, Y. J. Lab. Clin. Med. (2000) [Pubmed]
  19. The influence of surgical transection and anastomosis on the rate of cell proliferation in the colonic epithelium of normal and DMH-treated rats. Barkla, D.H., Tutton, P.M. Carcinogenesis (1983) [Pubmed]
  20. Toxic megacolon of ulcerative colitis in infancy. Karjoo, M., McCarthy, B. Pediatrics (1976) [Pubmed]
  21. Role of tachykinins in castor oil diarrhoea in rats. Croci, T., Landi, M., Emonds-Alt, X., Le Fur, G., Maffrand, J.P., Manara, L. Br. J. Pharmacol. (1997) [Pubmed]
  22. In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips. Croci, T., Aureggi, G., Guagnini, F., Manara, L., Gully, D., Fur, G.L., Maffrand, J.P., Mukenge, S., Ferla, G., Ferrara, P., Chalon, P., Vita, N. Br. J. Pharmacol. (1999) [Pubmed]
  23. The effects of cisapride on the quality and tolerance of colonic lavage: a double-blind randomized study. Reiser, J.R., Rosman, A.S., Rajendran, S.K., Berner, J.S., Korsten, M.A. Gastrointest. Endosc. (1995) [Pubmed]
  24. Impact of KRAS and TP53 mutations on survival in patients with left- and right-sided Dukes' C colon cancer. Bleeker, W.A., Hayes, V.M., Karrenbeld, A., Hofstra, R.M., Hermans, J., Buys, C.C., Plukker, J.T. Am. J. Gastroenterol. (2000) [Pubmed]
  25. CDX-2 expression is reduced in colorectal carcinomas with solid growth pattern and proximal location, but is largely independent of MSI status. Okoń, K., Zazula, M., Rudzki, Z., Papla, B., Osuch, C., Stachura, J. Polish journal of pathology : official journal of the Polish Society of Pathologists. (2004) [Pubmed]
  26. Alpha-fetoprotein-producing carcinoma of the colon: report of a case and review of the literature. Yachida, S., Fukushima, N., Nakanishi, Y., Akasu, T., Kitamura, H., Sakamoto, M., Shimoda, T. Dis. Colon Rectum (2003) [Pubmed]
  27. Factors affecting local recurrence of colonic adenocarcinoma. Harris, G.J., Church, J.M., Senagore, A.J., Lavery, I.C., Hull, T.L., Strong, S.A., Fazio, V.W. Dis. Colon Rectum (2002) [Pubmed]
  28. A possible central serotonergic mechanism involved in the effects of morphine on colonic motility in dog. Bueno, L., Fioramonti, J. Eur. J. Pharmacol. (1982) [Pubmed]
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