Disease relevance of xylR

• Nucleotide sequence of the regulatory gene xylR of the TOL plasmid from Pseudomonas putida [1].

High impact information on xylR

• The results of the above experiments provide evidence that xylR positively controls the transcription of xylS in the presence of m-xylene or m-methylbenzyl alcohol [2].
• Expression of the regulatory gene xylS on the TOL plasmid is positively controlled by the xylR gene product [2].
• The gene also activates the transcription of the same operon in the presence of m-xylene or m-methylbenzyl alcohol, but for this activation another regulatory gene, xylR, is required [2].
• The xylR gene is a regulatory gene on the TOL plasmid, which acts in a positive manner on xyl operons for degradation of toluene and xylenes in Pseudomonas putida [3].
• Determination of the transcription initiation site and identification of the protein product of the regulatory gene xylR for xyl operons on the TOL plasmid [3].

Chemical compound and disease context of xylR

• Transcription of the first operon coding for m-xylene-degrading enzymes on the TOL plasmid of Pseudomonas putida is activated by the xylR gene product in the presence of m-xylene [4].

Biological context of xylR

• The first, the upper operon, is controlled by the xylR regulatory gene, whereas the second, the meta operon, is controlled by the xylS regulatory gene [5].

Associations of xylR with chemical compounds

• Insertion mutations of the xylR and xylS regulatory genes of the catabolic pathway have been isolated and characterized and their ability to induce catechol 2,3-oxygenase activity determined [6].

Regulatory relationships of xylR

• The xylS gene itself is subjected to control by xylR [5].

Other interactions of xylR

• Four recombinant mini-Tn5 transposons are described which contain outward-facing Pm, Pu or Psal promoters from the catabolic plasmids TOL and NAH of Pseudomonas putida, along with their cognate wild-type regulatory genes (xylS, xylR, nahR) or mutant varieties (xylS2) [7].

Analytical, diagnostic and therapeutic context of xylR

• These bacterial biosensors are based on fusions of a promoter that is sensitive to aromatic compounds (the promoter region of the xylS gene and the xylR gene coding for the transcriptional regulator of the xyl operon) to reporter genes that can be monitored electrochemically at real-time and on-line [8].
• Genetic, functional and sequence analysis of the xylR and xylS regulatory genes of the TOL plasmid pWW0 [6].

References