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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Bub3  -  budding uninhibited by benzimidazoles 3...

Mus musculus

Synonyms: AU019800, AU021329, AU043350, AW146323, C78067, ...
 
 
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High impact information on Bub3

  • Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice [1].
  • Crossing Bub3(+/-) mice onto a heterozygous tumor-suppressor background of Trp53 or Rb1 similarly revealed no substantial differences in either the number or the rate at which tumors appeared [2].
  • To investigate the role of Bub3 in chromosome segregation and cancer development, we analyzed haploinsufficient cells in mice [2].
  • Heterozygous Bub3 embryonic fibroblasts displayed increased aneuploidy and premature sister-chromatid separation [2].
 

Biological context of Bub3

  • Disruption of Mad2, BubR1, Bub3 or Rae1 in mice results in substantial aneuploidy in somatic tissues, but whether these genes are equally important for accurate chromosome segregation during meiosis has not yet been established [3].
  • Furthermore, although BubR1 hypomorphic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster [1].

References

  1. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. Baker, D.J., Jeganathan, K.B., Malureanu, L., Perez-Terzic, C., Terzic, A., van Deursen, J.M. J. Cell Biol. (2006) [Pubmed]
  2. Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Kalitsis, P., Fowler, K.J., Griffiths, B., Earle, E., Chow, C.W., Jamsen, K., Choo, K.H. Genes Chromosomes Cancer (2005) [Pubmed]
  3. Differential mitotic checkpoint protein requirements in somatic and germ cells. Jeganathan, K.B., van Deursen, J.M. Biochem. Soc. Trans. (2006) [Pubmed]
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