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Gene Review

BUB3  -  BUB3 mitotic checkpoint protein

Homo sapiens

Synonyms: BUB3L, Mitotic checkpoint protein BUB3, hBUB3
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Disease relevance of BUB3


High impact information on BUB3

  • We propose that the structure imposed on the GLEBS segment by its association with Bub3 enables recruitment to unattached kinetochores [5].
  • This mitotic slippage is correlated with diminished expression of cdc2 kinase, topoisomerase IIalpha, BUB3, and BUB2-like protein 1, as well as with an increased expression of 14-3-3-sigma [6].
  • These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progression of tobacco smoke-induced adenocarcinoma of the lung [7].
  • The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins [8].
  • Chromatin immunoprecipitation localized E2F4 at promoter regions of the Bub3 and Pttg1 mitotic genes following irradiation, which were among the downregulated genes identified by the microarray [9].

Biological context of BUB3


Anatomical context of BUB3

  • The fibroblast growth factor receptor 2 (FGFR2) gene is located 2 Mb from the BUB3 gene and has the potential for a role in cancer [2].

Associations of BUB3 with chemical compounds


Other interactions of BUB3

  • These results suggest that inactivation of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 by epigenetic silencing does not seem to play a role in gastric carcinogenesis [1].
  • Here, we show that Bub3 and Cdc20 form a complex with histone deacetylases; this interaction appears to confer transcriptional repressor activity in a heterologous DNA-binding context [12].

Analytical, diagnostic and therapeutic context of BUB3


  1. Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation. Grabsch, H., Takeno, S., Parsons, W.J., Pomjanski, N., Boecking, A., Gabbert, H.E., Mueller, W. J. Pathol. (2003) [Pubmed]
  2. Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. Mendoza, S., David, H., Gaylord, G.M., Miller, C.W. Cancer Genet. Cytogenet. (2005) [Pubmed]
  3. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Hernando, E., Orlow, I., Liberal, V., Nohales, G., Benezra, R., Cordon-Cardo, C. Int. J. Cancer (2001) [Pubmed]
  4. Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. Reis, R.M., Nakamura, M., Masuoka, J., Watanabe, T., Colella, S., Yonekawa, Y., Kleihues, P., Ohgaki, H. Acta Neuropathol. (2001) [Pubmed]
  5. Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Larsen, N.A., Al-Bassam, J., Wei, R.R., Harrison, S.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Chen, J.G., Yang, C.P., Cammer, M., Horwitz, S.B. Cancer Res. (2003) [Pubmed]
  7. Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Miura, K., Bowman, E.D., Simon, R., Peng, A.C., Robles, A.I., Jones, R.T., Katagiri, T., He, P., Mizukami, H., Charboneau, L., Kikuchi, T., Liotta, L.A., Nakamura, Y., Harris, C.C. Cancer Res. (2002) [Pubmed]
  8. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. Wang, X., Babu, J.R., Harden, J.M., Jablonski, S.A., Gazi, M.H., Lingle, W.L., de Groen, P.C., Yen, T.J., van Deursen, J.M. J. Biol. Chem. (2001) [Pubmed]
  9. E2F4 regulates a stable G(2) arrest response to genotoxic stress in prostate carcinoma. Crosby, M.E., Jacobberger, J., Gupta, D., Macklis, R.M., Almasan, A. Oncogene (2007) [Pubmed]
  10. Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Lee, K.H., Yim, E.K., Kim, C.J., Namkoong, S.E., Um, S.J., Park, J.S. Gynecol. Oncol. (2005) [Pubmed]
  11. Proteomic evidence for roles for nucleolin and poly[ADP-ribosyl] transferase in drug resistance. Fu, Z., Fenselau, C. J. Proteome Res. (2005) [Pubmed]
  12. WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase. Yoon, Y.M., Baek, K.H., Jeong, S.J., Shin, H.J., Ha, G.H., Jeon, A.H., Hwang, S.G., Chun, J.S., Lee, C.W. FEBS Lett. (2004) [Pubmed]
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