Disease relevance of iaaH

• The iaaM and iaaH genes of Agrobacterium tumefaciens and Agrobacterium rhizogenes play an important role in crown gall and hairy root disease [1].
• Molecular cloning of a gene for indole-3-acetamide hydrolase from Bradyrhizobium japonicum [2].

High impact information on iaaH

• We conclude that the transcript 2 gene of pTiA6 codes for an enzyme that participates in auxin biosynthesis, probably an indoleacetamide hydrolase [3].
• Two oncogenes encode enzymes that convert tryptophan to indole-3-acetic acid (auxin): iaaM (tryptophan mono-oxygenase) and iaaH (indole-3-acetamide hydrolase) [4].
• We have identified a new insertion sequence, IS866, located in the auxin synthesis gene TA iaaH of Tm4, a wide host range biotype III octopine/cucumopine type Agrobacterium tumefaciens strain with two T regions on its tumor-inducing (Ti) plasmid, TA, and TB [5].

Associations of iaaH with chemical compounds

• There is perhaps a cooperation between iaaM, iaaH, and trp genes in the plasmid during plant cell transformation [6].

Analytical, diagnostic and therapeutic context of iaaH

• METHODS AND RESULTS: Three newly designed primers complementary to tms2 gene amplified DNA of only the tumor-inducing agrobacteria of 113 strains tested, resulting in 617 bp and 458 bp products in the first and second rounds of semi-nested PCR respectively [7].

References