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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Capn6  -  calpain 6

Mus musculus

Synonyms: Calpain-6, Capa6
 
 
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High impact information on Capn6

  • Capn6 mRNA is exclusively expressed during embryogenesis predominantly in developing skeletal and heart muscle overlapping closely with Capn3 expression domains [1].
  • Here we report the mRNA expression patterns during mouse development of the recently identified Capn5, Capn6 and Capn11 genes [1].
  • Expression was also observed in specific cells of the lung, kidney and placenta and in various epithelial cell types where the Capn6 mRNA appeared to be localized within the cell to the basal and apical ends [1].
  • The predicted Capn6 protein lacks critical active site residues and may not be proteolytically active [2].
  • Both genes are differentially expressed in human tissues with highest RNA levels for Capn5 occurring in the testis, liver, trachea, colon, and kidney, while Capn6 is highly expressed only in the placenta sample of the 50 tissues examined [2].

References

  1. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear, T.N., Boehm, T. Mech. Dev. (1999) [Pubmed]
  2. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Dear, N., Matena, K., Vingron, M., Boehm, T. Genomics (1997) [Pubmed]
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