Gene Review:
Capn3 - calpain 3
Mus musculus
Synonyms:
AI323605, CANP 3, Calcium-activated neutral proteinase 3, Calpain L3, Calpain p94, ...
- Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal components. Taveau, M., Bourg, N., Sillon, G., Roudaut, C., Bartoli, M., Richard, I. Mol. Cell. Biol. (2003)
- Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice. Richard, I., Roudaut, C., Marchand, S., Baghdiguian, S., Herasse, M., Stockholm, D., Ono, Y., Suel, L., Bourg, N., Sorimachi, H., Lefranc, G., Fardeau, M., Sébille, A., Beckmann, J.S. J. Cell Biol. (2000)
- Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation. Spencer, M.J., Guyon, J.R., Sorimachi, H., Potts, A., Richard, I., Herasse, M., Chamberlain, J., Dalkilic, I., Kunkel, L.M., Beckmann, J.S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice. Nakamura, Y., Fukiage, C., Shih, M., Ma, H., David, L.L., Azuma, M., Shearer, T.R. Invest. Ophthalmol. Vis. Sci. (2000)
- Third form of calcium-activated neutral proteinase from calf brain: purification, partial characterization and comparison of properties with other forms. Malik, M.N., Fenko, M.D., Sheikh, A.M., Kascsak, R.J., Tonna-DeMasi, M.S., Wisniewski, H.M. Biochim. Biophys. Acta (1987)
- Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway. Kramerova, I., Kudryashova, E., Venkatraman, G., Spencer, M.J. Hum. Mol. Genet. (2005)
- Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear, T.N., Boehm, T. Mech. Dev. (1999)
- Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. Ono, Y., Kakinuma, K., Torii, F., Irie, A., Nakagawa, K., Labeit, S., Abe, K., Suzuki, K., Sorimachi, H. J. Biol. Chem. (2004)
- Bidirectional transcriptional activity of the Pgk1 promoter and transmission ratio distortion in Capn3-deficient mice. Taveau, M., Stockholm, D., Marchand, S., Roudaut, C., Le Bert, M., Richard, I. Genomics (2004)
- Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Reed, N.A., Castellini, M.A., Ma, H., Shearer, T.R., Duncan, M.K. Exp. Eye Res. (2003)
- Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling. Witt, C.C., Ono, Y., Puschmann, E., McNabb, M., Wu, Y., Gotthardt, M., Witt, S.H., Haak, M., Labeit, D., Gregorio, C.C., Sorimachi, H., Granzier, H., Labeit, S. J. Mol. Biol. (2004)
- Lp82 is the dominant form of calpain in young mouse lens. Ma, H., Hata, I., Shih, M., Fukiage, C., Nakamura, Y., Azuma, M., Shearer, T.R. Exp. Eye Res. (1999)
- Down-regulation of genes in the lysosomal and ubiquitin-proteasome proteolytic pathways in calpain-3-deficient muscle. Combaret, L., Béchet, D., Claustre, A., Taillandier, D., Richard, I., Attaix, D. Int. J. Biochem. Cell Biol. (2003)
- Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human. Richard, I., Beckmann, J.S. Mamm. Genome (1996)
- Highly conserved structure in the promoter region of the gene for muscle-specific calpain, p94. Sorimachi, H., Forsberg, N.E., Lee, H.J., Joeng, S.Y., Richard, I., Beckmann, J.S., Ishiura, S., Suzuki, K. Biol. Chem. (1996)
- Calpain 3 is expressed in astrocytes of rat and Microcebus brain. König, N., Raynaud, F., Feane, H., Durand, M., Mestre-Francès, N., Rossel, M., Ouali, A., Benyamin, Y. J. Chem. Neuroanat. (2003)
- Physiological correlation between glycyrrhizin, glycyrrhizin-binding lipoxygenase and casein kinase II. Shimoyama, Y., Ohtaka, H., Nagata, N., Munakata, H., Hayashi, N., Ohtsuki, K. FEBS Lett. (1996)