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Gene Review

Capn11  -  calpain 11

Mus musculus

Synonyms: CANP 11, Calcium-activated neutral proteinase 11, Calpain-11
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Disease relevance of Capn11

  • Inhibition of calpain activity by the N-benzyloxycarbonyl-Val-Phe-aldehyde (MDL28170) blocked the TCDD-induced nuclear translocation of AhR in Hepa1c1c7 mouse hepatoma cell line [1].
  • Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia [2].
  • Calpain activation and secretion promote glomerular injury in experimental glomerulonephritis: evidence from calpastatin-transgenic mice [3].
  • Wild-type mice that were subjected to anti-glomerular basement membrane nephritis exhibited elevated levels of calpain activity in kidney cortex at the heterologous phase of the disease [3].
  • There also was a reduction in nephrin disappearance from the surface of podocytes, indicating that calpain activity would enhance proteinuria by affecting nephrin expression [3].

Psychiatry related information on Capn11


High impact information on Capn11


Chemical compound and disease context of Capn11


Biological context of Capn11


Anatomical context of Capn11


Associations of Capn11 with chemical compounds


Analytical, diagnostic and therapeutic context of Capn11

  • On Western blot analysis, calpain protein was increased 2-3-fold at 3-5 days after infection with ARHI adenovirus [21].
  • At various intervals up to 2 weeks after injury, optic nerves were examined for neurofilament proteins and calpain-mediated spectrin breakdown products using immunohistochemistry [22].
  • The calcium-dependent neutral protease calpain has putative roles in cytoskeletal and membrane changes in other cellular processes; this fact led us to test the role of calpain in a well-known model of apoptotic cell death, that of thymocytes after treatment with dexamethasone [23].
  • (3) Immunoblotting showed that conversion of the larger calpain I subunit from 80 kDa into 76-78 kDa occurred only when thrombin-activated platelets were stirred to permit aggregation, and did not occur during unstirred thrombin activation [24].
  • Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum [25].


  1. Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Dale, Y.R., Eltom, S.E. Mol. Pharmacol. (2006) [Pubmed]
  2. Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia. Shioda, N., Moriguchi, S., Shirasaki, Y., Fukunaga, K. J. Neurochem. (2006) [Pubmed]
  3. Calpain activation and secretion promote glomerular injury in experimental glomerulonephritis: evidence from calpastatin-transgenic mice. Peltier, J., Bellocq, A., Perez, J., Doublier, S., Dubois, Y.C., Haymann, J.P., Camussi, G., Baud, L. J. Am. Soc. Nephrol. (2006) [Pubmed]
  4. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Battaglia, F., Trinchese, F., Liu, S., Walter, S., Nixon, R.A., Arancio, O. J. Mol. Neurosci. (2003) [Pubmed]
  5. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Franco, S.J., Rodgers, M.A., Perrin, B.J., Han, J., Bennin, D.A., Critchley, D.R., Huttenlocher, A. Nat. Cell Biol. (2004) [Pubmed]
  6. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. Wang, N., Chen, W., Linsel-Nitschke, P., Martinez, L.O., Agerholm-Larsen, B., Silver, D.L., Tall, A.R. J. Clin. Invest. (2003) [Pubmed]
  7. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. Nakagawa, T., Yuan, J. J. Cell Biol. (2000) [Pubmed]
  8. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. Noguchi, M., Sarin, A., Aman, M.J., Nakajima, H., Shores, E.W., Henkart, P.A., Leonard, W.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. Hou, S.T., Jiang, S.X., Desbois, A., Huang, D., Kelly, J., Tessier, L., Karchewski, L., Kappler, J. J. Neurosci. (2006) [Pubmed]
  10. Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury. Zhou, J., Wu, Y., Henderson, F., McCoy, D.M., Salome, R.G., McGowan, S.E., Mallampalli, R.K. Gene Ther. (2006) [Pubmed]
  11. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Mishizen-Eberz, A.J., Guttmann, R.P., Giasson, B.I., Day, G.A., Hodara, R., Ischiropoulos, H., Lee, V.M., Trojanowski, J.Q., Lynch, D.R. J. Neurochem. (2003) [Pubmed]
  12. Selective Deletion of the NH(2)-Terminal Variable Region of Cardiac Troponin T in Ischemia Reperfusion by Myofibril-Associated mu-Calpain Cleavage. Zhang, Z., Biesiadecki, B.J., Jin, J.P. Biochemistry (2006) [Pubmed]
  13. Establishment of Schistosoma japonicum calpain-specific mouse T cell hybridomas and identification of a T cell epitope that stimulates IFNgamma production. Osada, Y., Kumagai, T., Hato, M., Suzuki, T., El-Malky, M., Asahi, H., Kanazawa, T., Ohta, N. Vaccine (2005) [Pubmed]
  14. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear, T.N., Boehm, T. Mech. Dev. (1999) [Pubmed]
  15. Calpain 11 is unique to mouse spermatogenic cells. Ben-Aharon, I., Brown, P.R., Shalgi, R., Eddy, E.M. Mol. Reprod. Dev. (2006) [Pubmed]
  16. A Mouse Model for Monitoring Calpain Activity under Physiological and Pathological Conditions. Bartoli, M., Bourg, N., Stockholm, D., Raynaud, F., Delevacque, A., Han, Y., Borel, P., Seddik, K., Armande, N., Richard, I. J. Biol. Chem. (2006) [Pubmed]
  17. Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Shao, H., Chou, J., Baty, C.J., Burke, N.A., Watkins, S.C., Stolz, D.B., Wells, A. Mol. Cell. Biol. (2006) [Pubmed]
  18. Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons. Momeni, H.R., Kanje, M. Neuroreport (2006) [Pubmed]
  19. Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit. Bretin, S., Rogemond, V., Marin, P., Maus, M., Torrens, Y., Honnorat, J., Glowinski, J., Prémont, J., Gauchy, C. J. Neurochem. (2006) [Pubmed]
  20. Calpain Is Required for the Rapid, Calcium-dependent Repair of Wounded Plasma Membrane. Mellgren, R.L., Zhang, W., Miyake, K., McNeil, P.L. J. Biol. Chem. (2007) [Pubmed]
  21. Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Bao, J.J., Le, X.F., Wang, R.Y., Yuan, J., Wang, L., Atkinson, E.N., LaPushin, R., Andreeff, M., Fang, B., Yu, Y., Bast, R.C. Cancer Res. (2002) [Pubmed]
  22. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. Saatman, K.E., Abai, B., Grosvenor, A., Vorwerk, C.K., Smith, D.H., Meaney, D.F. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  23. Calpain activation in apoptosis. Squìer, M.K., Miller, A.C., Malkinson, A.M., Cohen, J.J. J. Cell. Physiol. (1994) [Pubmed]
  24. Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies. Samis, J.A., Zboril, G., Elce, J.S. Biochem. J. (1987) [Pubmed]
  25. Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum. Zhang, R., Yoshida, A., Kumagai, T., Kawaguchi, H., Maruyama, H., Suzuki, T., Itoh, M., El-Malky, M., Ohta, N. Infect. Immun. (2001) [Pubmed]
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