The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Capn5  -  calpain 5

Mus musculus

Synonyms: Calpain-5, Ncl3, New calpain 3, nCL-3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Capn5


High impact information on Capn5

  • In the thymus, Capn5 was expressed mainly in relatively immature CD25(+) embryonic thymocytes [1].
  • Capn5 is expressed in a subset of T cells and is dispensable for development [1].
  • There were no defects in the major T- or B-cell populations in the thymus, spleen, bone marrow, or peritoneum, nor did apoptosis appear abnormal in Capn5-null T cells [1].
  • The Capn5 gene was inactivated by homologous recombination in ES cells that subsequently colonized the germ line of mice [1].
  • Refined mapping of Capn5, also previously localized to chromosome 7, indicated that it was not closely linked to Capn12, mapping tightly linked to a marker positioned at 48.5 cM [3].

Biological context of Capn5


Anatomical context of Capn5

  • Both genes are differentially expressed in human tissues with highest RNA levels for Capn5 occurring in the testis, liver, trachea, colon, and kidney, while Capn6 is highly expressed only in the placenta sample of the 50 tissues examined [5].

Other interactions of Capn5

  • Here we report the mRNA expression patterns during mouse development of the recently identified Capn5, Capn6 and Capn11 genes [4].


WikiGenes - Universities