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Cd19  -  CD19 antigen

Mus musculus

Synonyms: AW495831, B-lymphocyte antigen CD19, Differentiation antigen CD19
 
 
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Disease relevance of Cd19

  • Bispecific antibodies (CD3x19) against the CD3epsilon-chain of the T-cell-receptor/CD3 complex and the CD19 antigen on B cells can target polyclonal, nontumor-specific T cells to B lymphoma cells [1].
  • Six patients with progressive B cell non-Hodgkin's lymphoma have been treated with an IgG2a mouse monoclonal antibody (mAb) against the B cell differentiation antigen CD19, with total doses varying from 225 mg to 1000 mg [2].
 

High impact information on Cd19

  • Twenty five percent of these human cells expressed the CD34 antigen, of which 90% coexpressed the CD38 antigen and 50% the CD19 antigen [3].
  • Anti-B4-blocked Ricin (Anti-B4-bR) is an immunotoxin comprised of the anti-B4 monoclonal antibody (MoAb) and the protein toxin "blocked ricin." The anti-B4 MoAb is directed against the B-lineage-restricted CD19 antigen expressed on more than 95% of normal and neoplastic B cells [4].
  • A differentiation-inducer, sodium butyrate (SB), encapsulated in liposomes conjugated covalently to a monoclonal antibody directed to CD19 antigen, was successfully targeted to human lymphoma cell lines SKLY-18 and Ramos grown in vitro and in vivo in nude mice [5].
  • Cd19-dependent activation of Akt kinase in B-lymphocytes [6].
  • At the age of 4 (young) and 8 (old) mo, MLN lymphocytes were isolated and B- (CD19(+)) and T-lymphocyte subsets (CD4(+) and CD8(+)) were determined by flow cytometry [7].
 

Anatomical context of Cd19

  • Lymphocyte subsets were detected by specific mouse monoclonal antibodies: Leu-4/CD3+ (T-cells), Leu-3a/CD4+ (T-helper cells), Leu-2a/CD8+ (T-suppressor-cytotoxic cells), Leu-11/19/CD16+/CD56+ (natural killer cells), and Leu-12/CD19+ (B-cells) [8].
 

Associations of Cd19 with chemical compounds

References

  1. Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "veto" apoptosis of antibody-targeted cytotoxic T cells. Daniel, P.T., Kroidl, A., Kopp, J., Sturm, I., Moldenhauer, G., Dörken, B., Pezzutto, A. Blood (1998) [Pubmed]
  2. Initial experience with treatment of human B cell lymphoma with anti-CD19 monoclonal antibody. Hekman, A., Honselaar, A., Vuist, W.M., Sein, J.J., Rodenhuis, S., ten Bokkel Huinink, W.W., Somers, R., Rümke, P., Melief, C.J. Cancer Immunol. Immunother. (1991) [Pubmed]
  3. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Pflumio, F., Izac, B., Katz, A., Shultz, L.D., Vainchenker, W., Coulombel, L. Blood (1996) [Pubmed]
  4. Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion. Grossbard, M.L., Freedman, A.S., Ritz, J., Coral, F., Goldmacher, V.S., Eliseo, L., Spector, N., Dear, K., Lambert, J.M., Blättler, W.A. Blood (1992) [Pubmed]
  5. Effect of liposomes containing sodium butyrate conjugated with anti-CD19 monoclonal antibody on in vitro and in vivo growth of malignant lymphoma. Watanabe, M., Pesando, J.M., Hakomori, S. Cancer Res. (1990) [Pubmed]
  6. Cd19-dependent activation of Akt kinase in B-lymphocytes. Otero, D.C., Omori, S.A., Rickert, R.C. J. Biol. Chem. (2001) [Pubmed]
  7. Dietary (n-6) and (n-3) fatty acids and energy restriction modulate mesenteric lymph node lymphocyte function in autoimmune-prone (NZB x NZW)F1 mice. Lim, B.O., Jolly, C.A., Zaman, K., Fernandes, G. J. Nutr. (2000) [Pubmed]
  8. Distribution of peripheral blood leukocytes in acute heatstroke. Bouchama, A., al Hussein, K., Adra, C., Rezeig, M., al Shail, E., al Sedairy, S. J. Appl. Physiol. (1992) [Pubmed]
  9. Preclinical investigation of the antitumour effects of anti-CD19-idarubicin immunoconjugates. Rowland, A.J., Pietersz, G.A., McKenzie, I.F. Cancer Immunol. Immunother. (1993) [Pubmed]
 
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